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Gene Review

tuf  -  elongation factor Tu

Mycoplasma pneumoniae M129

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Disease relevance of tuf


High impact information on tuf

  • The relatively low G + C content (40%) of the M. pneumoniae DNA was reflected in a low G + C content (44.6%) of the tuf gene, and in a preferential use of adenine and uracil at the third position of codons, yet codon usage analysis revealed the presence of almost all of the codons of the genetic code in the mycoplasmal gene [1].
  • The nucleotide sequence of the mycoplasmal gene showed about 60% homology to the sequences of tuf genes of other prokaryotes, yeast mitochondria and Euglena gracilis chloroplasts, and about 75% similarity was found when comparing the deduced amino acid sequences of the various Tu proteins [1].


  1. Nucleotide sequence and codon usage of the elongation factor Tu(EF-Tu) gene from Mycoplasma pneumoniae. Yogev, D., Sela, S., Bercovier, H., Razin, S. Mol. Microbiol. (1990) [Pubmed]
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