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Gene Review

amiC  -  aliphatic amidase expression-regulating...

Pseudomonas aeruginosa PAO1

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Disease relevance of amiC

  • Using in vitro-constructed deletions and subcloned DNA fragments, we have identified a new gene, amiC, which regulates expression of the inducible Pseudomonas aeruginosa aliphatic amidase activity [1].

High impact information on amiC

  • This promoter would be expected to provide basal levels of expression of the amiC and amiR regulatory genes to allow induction of the system [2].
  • Previously, two RpoN-dependent promoter-like sequences (pN1 and pN2) were identified upstream of the negative regulator gene, amiC, and we have now constructed a promoter probe vector which shows weak constitutive promoter activity within this region [2].
  • Disruption of the amiC open reading frame by insertion and deletion leads to constitutive amidase synthesis, suggesting that AmiC is a negative regulator [1].

Biological context of amiC

  • The amiC translation termination codon (A)TGA overlaps the initiation codon for the downstream amiR transcription antitermination factor gene, implying that the amiCR operon is coordinately regulated [1].
  • Cloning and DNA sequence of amiC, a new gene regulating expression of the Pseudomonas aeruginosa aliphatic amidase, and purification of the amiC product [1].


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