Disease relevance of mucC

• Role of Azotobacter vinelandii mucA and mucC gene products in alginate production [1].
• Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity [2].

High impact information on mucC

• A transcriptional start site for a mucD promoter (PmucD) was mapped within mucC [3].
• Inactivation of mucC in mucA or mucB mutant backgrounds resulted in a mucoid phenotype when the cells were grown under combined stress conditions of elevated temperature and osmolarity [2].
• These findings support a negative regulatory role of mucC in alginate production by P. aeruginosa, indicate additive effects of muc genes in the regulation of mucoidy in this organism and suggest that multiple stress signals and recognition systems participate in the regulation of algU-dependent functions [2].

Biological context of mucC

• In this work, we studied the transcriptional regulation of the A. vinelandii algU-mucABCD gene cluster, as well as the role of the mucA and mucC gene products in alginate production [1].

References