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Gene Review:

mexT - transcriptional regulator MexT

Pseudomonas aeruginosa PAO1

Quale, J. et al., Ochs, M.M. et al., Maseda, H. et al., Köhler, T. et al., Bratu, S. et al., et al.

Quale, Bratu, Gupta, Landman, Köhler, Epp, Curty, Pechère,

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Disease relevance of mexT

By using T7-polymerase, a 34-kDa protein was expressed in Escherichia coli from a plasmid carrying the mexT gene [1].
Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa [2].

High impact information on mexT

The sequencing of regulatory genes (ampR, mexR, nalC, nalD, mexT, and mexZ) was also performed [3].
To investigate the negative regulatory mechanisms influencing oprD expression, a gene upstream of the coregulated mexEF-oprN efflux operon, designated mexT, was cloned [4].
There were no mutations in lasI, rhlI, mexT or mexS that correlated with quorum-sensing expression [5].
We show that mvaT mutation does not affect mexEF-oprN expression through mexT or mexS [6].

References

Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. Köhler, T., Epp, S.F., Curty, L.K., Pechère, J.C. J. Bacteriol. (1999) [Pubmed]
Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa. Maseda, H., Saito, K., Nakajima, A., Nakae, T. FEMS Microbiol. Lett. (2000) [Pubmed]
Interplay of Efflux System, ampC, and oprD Expression in Carbapenem Resistance of Pseudomonas aeruginosa Clinical Isolates. Quale, J., Bratu, S., Gupta, J., Landman, D. Antimicrob. Agents Chemother. (2006) [Pubmed]
Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids. Ochs, M.M., McCusker, M.P., Bains, M., Hancock, R.E. Antimicrob. Agents Chemother. (1999) [Pubmed]
Expression of the las and rhl quorum-sensing systems in clinical isolates of Pseudomonas aeruginosa does not correlate with efflux pump expression or antimicrobial resistance. Bratu, S., Gupta, J., Quale, J. J. Antimicrob. Chemother. (2006) [Pubmed]
mvaT mutation modifies the expression of the Pseudomonas aeruginosa multidrug efflux operon mexEF-oprN. Westfall, L.W., Carty, N.L., Layland, N., Kuan, P., Colmer-Hamood, J.A., Hamood, A.N. FEMS Microbiol. Lett. (2006) [Pubmed]

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