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Gene Review

mvaT  -  transcriptional regulator MvaT

Pseudomonas aeruginosa PAO1

 
 
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Disease relevance of mvaT

 

High impact information on mvaT

  • MvaT was identified as a novel global regulator of virulence gene expression, as a mutation in mvaT resulted in enhanced lecA expression and pyocyanin production [2].
  • The effect of mvaT on ptxS and ptxR expression was examined using real-time PCR experiments [3].
  • Expression of mexEF-oprN is increased by five- to sixfold in PAODeltamvaT, while the expression of oprD is reduced by approximately twofold. mvaT mutation had no effect on the expression of other multidrug resistance operons, although it increased the expression of several ATP-binding cassette transporter genes [1].
  • We show that mvaT mutation does not affect mexEF-oprN expression through mexT or mexS [1].
  • In this study, we show that the mvaT mutant PAODeltamvaT is more resistant than its parent PAO1 strain to chloramphenicol and norfloxacin but more sensitive to imipenem; yet both were less resistant to chloramphenicol, norfloxacin, and imipenem than 'typical'nfxC-type mutants [1].

References

  1. mvaT mutation modifies the expression of the Pseudomonas aeruginosa multidrug efflux operon mexEF-oprN. Westfall, L.W., Carty, N.L., Layland, N., Kuan, P., Colmer-Hamood, J.A., Hamood, A.N. FEMS Microbiol. Lett. (2006) [Pubmed]
  2. Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression. Diggle, S.P., Winzer, K., Lazdunski, A., Williams, P., Cámara, M. J. Bacteriol. (2002) [Pubmed]
  3. The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Westfall, L.W., Luna, A.M., San Francisco, M., Diggle, S.P., Worrall, K.E., Williams, P., Cámara, M., Hamood, A.N. Microbiology (Reading, Engl.) (2004) [Pubmed]
 
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