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Gene Review:

arcC - carbamate kinase

Pseudomonas aeruginosa PAO1

Abdelal, A.T. et al., Ruepp, A. et al., Hass, D. et al., Gamper, M. et al., D'Hooghe, I. et al.

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Disease relevance of arcC

Carbamate kinase from Pseudomonas aeruginosa: purification, characterization, physiological role, and regulation [1].

High impact information on arcC

Dot blot experiments revealed that arc mRNAs extracted from the wild-type strain had similar chemical half-lives in the arcA, arcB and arcC regions, ranging from 16 to 13 minutes [2].
R. etli arcA mutants, with polar effects on arcB and arcC, were constructed by insertion mutagenesis [3].
Pseudomonas aeruginosa PAO1 possessed a carbamate kinase (CKase) distinct from carbamoylphosphate synthetase as well as from a constitutive acetate kinase which also catalyzes the phosphorylation of ADP by carbamoylphosphate [1].

Chemical compound and disease context of arcC

In Pseudomonas aeruginosa arginine can be degraded by the arginine "dihydrolase" system, consisting of arginine deiminase, catabolic ornithine carbamoyltransferase, and carbamate kinase [4].

Other interactions of arcC

The identification of the arcC and arcA genes was verified, respectively, by heterologous expression of the enzyme in Haloferax volcanii and by protein isolation and N-terminal sequence determination of three peptides [5].

References

Carbamate kinase from Pseudomonas aeruginosa: purification, characterization, physiological role, and regulation. Abdelal, A.T., Bibb, W.F., Nainan, O. J. Bacteriol. (1982) [Pubmed]
RNA processing modulates the expression of the arcDABC operon in Pseudomonas aeruginosa. Gamper, M., Ganter, B., Polito, M.R., Haas, D. J. Mol. Biol. (1992) [Pubmed]
The arginine deiminase pathway in Rhizobium etli: DNA sequence analysis and functional study of the arcABC genes. D'Hooghe, I., Vander Wauven, C., Michiels, J., Tricot, C., de Wilde, P., Vanderleyden, J., Stalon, V. J. Bacteriol. (1997) [Pubmed]
Genetic and physiological characterization of Pseudomonas aeruginosa mutants affected in the catabolic ornithine carbamoyltransferase. Hass, D., Evans, R., Mercenier, A., Simon, J.P., Stalon, V. J. Bacteriol. (1979) [Pubmed]
Fermentative arginine degradation in Halobacterium salinarium (formerly Halobacterium halobium): genes, gene products, and transcripts of the arcRACB gene cluster. Ruepp, A., Soppa, J. J. Bacteriol. (1996) [Pubmed]

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