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oprN  -  Multidrug efflux outer membrane protein...

Pseudomonas aeruginosa PAO1

 
 
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Disease relevance of oprN

 

High impact information on oprN

  • The mutant cells lacking MexF produced undetectable OprN and only a full-size of MexE even though the cells had unimpaired oprN and mexE [2].
  • A cosmid clone harbouring the oprN gene was isolated by partial complementation of a mutant deficient in OprM, the outer membrane component of the mexAB-oprM efflux operon [3].
  • The results showed that oprD was relatively stable against carbapenem antibiotics. oprM was induced significantly by imipenem in only one strain and oprN was induced by imipenem in most of the strains [1].
 

Other interactions of oprN

  • The level of oprN mRNA was significantly up-regulated, while the oprD gene was down-regulated (although this difference was statistically insignificant), in the mutants [4].

References

  1. Effect of carbapenems on the transcriptional expression of the oprD, oprM and oprN genes in Pseudomonas aeruginosa. Kolayli, F., Karadenizli, A., Savli, H., Ergen, K., Hatirnaz, O., Balikci, E., Budak, F., Vahaboglu, H. J. Med. Microbiol. (2004) [Pubmed]
  2. A novel assembly process of the multicomponent xenobiotic efflux pump in Pseudomonas aeruginosa. Maseda, H., Kitao, M., Eda, S., Yoshihara, E., Nakae, T. Mol. Microbiol. (2002) [Pubmed]
  3. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Köhler, T., Michéa-Hamzehpour, M., Henze, U., Gotoh, N., Curty, L.K., Pechère, J.C. Mol. Microbiol. (1997) [Pubmed]
  4. Expression stability of six housekeeping genes: A proposal for resistance gene quantification studies of Pseudomonas aeruginosa by real-time quantitative RT-PCR. Savli, H., Karadenizli, A., Kolayli, F., Gundes, S., Ozbek, U., Vahaboglu, H. J. Med. Microbiol. (2003) [Pubmed]
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