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Gene Review:

ftsZ - cell division protein FtsZ

Mycobacterium tuberculosis H37Rv

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Disease relevance of ftsZ

Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis [1].
Finally, we show that Mycobacterium smegmatis ftsZ mutant strains producing corresponding mutant FtsZ proteins are non-viable indicating that mutant FtsZ proteins cannot function as the sole source for FtsZ, a result distinctly different from that reported for Escherichia coli [2].

High impact information on ftsZ

Multiple promoters drive the expression of the principal cell division gene, ftsZ, in bacterial systems [1].
Expression of ftsZ from the dnaA promoter in M. smegmatis resulted in approximately sixfold overproduction and the merodiploids exhibited slow growth, an increased tendency to clump and filament, and in some cases produced buds and branches [3].
Following the infection of mice with M. tuberculosis, expression levels of rv1651c and rv0746 normalized to ftsZ and 16S rRNA were highest in the spleen tissue during the chronic stages of murine tuberculosis, with a >20- and >30-fold up-regulation, respectively [4].
To test the use of the tetracycline-inducible system for conditional gene silencing, mycobacteria were transformed with a pMind construct with tetRO driving expression of antisense RNA for the ftsZ gene [5].

Associations of ftsZ with chemical compounds

To further understand the roles of ftsZ in cell division a conditionally complementing ftsZ(smeg) mutant strain was constructed in which ftsZ expression is controlled by acetamide [6].

Analytical, diagnostic and therapeutic context of ftsZ

Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ [7].

References

Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis. Roy, S., Ajitkumar, P. J. Bacteriol. (2005) [Pubmed]
Mutations in the GTP-binding and synergy loop domains of Mycobacterium tuberculosis ftsZ compromise its function in vitro and in vivo. Rajagopalan, M., Atkinson, M.A., Lofton, H., Chauhan, A., Madiraju, M.V. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
Physiological consequences associated with overproduction of Mycobacterium tuberculosis FtsZ in mycobacterial hosts. Dziadek, J., Madiraju, M.V., Rutherford, S.A., Atkinson, M.A., Rajagopalan, M. Microbiology (Reading, Engl.) (2002) [Pubmed]
PE_PGRS proteins are differentially expressed by Mycobacterium tuberculosis in host tissues. Delogu, G., Sanguinetti, M., Pusceddu, C., Bua, A., Brennan, M.J., Zanetti, S., Fadda, G. Microbes Infect. (2006) [Pubmed]
Tetracycline-inducible gene regulation in mycobacteria. Blokpoel, M.C., Murphy, H.N., O'Toole, R., Wiles, S., Runn, E.S., Stewart, G.R., Young, D.B., Robertson, B.D. Nucleic Acids Res. (2005) [Pubmed]
Conditional expression of Mycobacterium smegmatis ftsZ, an essential cell division gene. Dziadek, J., Rutherford, S.A., Madiraju, M.V., Atkinson, M.A., Rajagopalan, M. Microbiology (Reading, Engl.) (2003) [Pubmed]
Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ. Leung, A.K., White, E.L., Ross, L.J., Borhani, D.W. Acta Crystallogr. D Biol. Crystallogr. (2000) [Pubmed]

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