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Gene Review

amiF  -  formamidase

Helicobacter pylori J99

 
 
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Disease relevance of jhp1159

 

High impact information on jhp1159

  • In contrast to other amidase-positive bacteria, amidase and formamidase enzyme activities were not induced by medium supplementation with their respective substrates, acrylamide and formamide [1].
  • H. pylori produces ammonia through urease-mediated degradation of urea, but it is also able to convert a range of amide substrates into ammonia via its AmiE amidase and AmiF formamidase enzymes [1].
  • This effect was not mediated at the transcriptional level, and Fur did not bind to the amiF promoter region [1].
  • Analysis of the complete H. pylori genome sequence revealed the existence of a duplicated amidase gene that we named amiF [2].
  • Phylogenetic trees based upon the sequences of H. pylori amiE and amiF genes and their respective homologs from other organisms as well as the amidase gene distribution among Helicobacter species are strongly suggestive of amidase acquisition by horizontal gene transfer [3].

References

  1. Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressor. van Vliet, A.H., Stoof, J., Poppelaars, S.W., Bereswill, S., Homuth, G., Kist, M., Kuipers, E.J., Kusters, J.G. J. Biol. Chem. (2003) [Pubmed]
  2. The AmiE aliphatic amidase and AmiF formamidase of Helicobacter pylori: natural evolution of two enzyme paralogues. Skouloubris, S., Labigne, A., De Reuse, H. Mol. Microbiol. (2001) [Pubmed]
  3. Presence of active aliphatic amidases in Helicobacter species able to colonize the stomach. Bury-Moné, S., Skouloubris, S., Dauga, C., Thiberge, J.M., Dailidiene, D., Berg, D.E., Labigne, A., De Reuse, H. Infect. Immun. (2003) [Pubmed]
 
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