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Gene Review

HP0840  -  UDP-N-acetylglucosamine 4,6-dehydratase

Helicobacter pylori 26695

 
 
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Disease relevance of HP0840

  • This mutant was complemented in trans with the homologous C. jejuni gene, as well as the Helicobacter pylori homologue, HP0840, which has been shown to encode a protein with UDP-GlcNAc C6-dehydratase/C4-reductase activity [1].
 

High impact information on HP0840

  • The Cj1293 and HP0840 enzymes exhibited C6 dehydratase as well as a newly identified C5 epimerase activity that resulted in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose [2].
  • The flaA1 mutant produced flagellins but no flagellum [3].
  • Overall, the similar phenotypes observed for both mutants and the complementation of the wbpB mutant by flaA1 suggest that both genes belong to the same biosynthesis pathway [3].
  • The data also suggest that flaA1 and wbpB are at the interface between several pathways that govern the expression of different virulence factors [3].
 

Chemical compound and disease context of HP0840

References

  1. Pseudaminic acid, the major modification on Campylobacter flagellin, is synthesized via the Cj1293 gene. Goon, S., Kelly, J.F., Logan, S.M., Ewing, C.P., Guerry, P. Mol. Microbiol. (2003) [Pubmed]
  2. Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways. Schoenhofen, I.C., McNally, D.J., Vinogradov, E., Whitfield, D., Young, N.M., Dick, S., Wakarchuk, W.W., Brisson, J.R., Logan, S.M. J. Biol. Chem. (2006) [Pubmed]
  3. The Helicobacter pylori flaA1 and wbpB genes control lipopolysaccharide and flagellum synthesis and function. Merkx-Jacques, A., Obhi, R.K., Bethune, G., Creuzenet, C. J. Bacteriol. (2004) [Pubmed]
 
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