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Gene Review:

ZNF622 - zinc finger protein 622

Homo sapiens

Synonyms: MGC17552, MGC2485, ZPR9, Zinc finger protein 622, Zinc finger-like protein 9

Seong, H.A. et al., Kleivi, K. et al., Seong, H.A. et al.

Kleivi, Lind, Diep, Meling, Brandal, Nesland, Myklebost, Rognum, Giercksky, Skotheim, Lothe,

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Disease relevance of ZNF622

Gains of chromosome arm 5p are common in peritoneal carcinomatoses and several candidate genes (including PTGER4, SKP2, and ZNF622) mapping to this region were overexpressed in the tumors [1].
These results strongly suggest that ZPR9 plays an important role in modulation of the transactivation by B-MYB and cellular growth of neuroblastoma cells [2].

High impact information on ZNF622

By using the yeast two-hybrid system, the zinc finger protein ZPR9 was identified as one of the B-MYB interacting proteins that associates with the carboxyl-terminal conserved region of B-MYB [2].
Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein [2].
Furthermore, constitutive expression of ZPR9 in human neuroblastoma cells induces apoptosis in the presence of retinoic acid [2].

Analytical, diagnostic and therapeutic context of ZNF622

The ZPR9 cDNA hybridized with a mRNA species of approx. 1.7 kb in Northern-blot analysis [3].

References

Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. Kleivi, K., Lind, G.E., Diep, C.B., Meling, G.I., Brandal, L.T., Nesland, J.M., Myklebost, O., Rognum, T.O., Giercksky, K.E., Skotheim, R.I., Lothe, R.A. Mol. Cancer (2007) [Pubmed]
Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. Seong, H.A., Kim, K.T., Ha, H. J. Biol. Chem. (2003) [Pubmed]
Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). Seong, H.A., Gil, M., Kim, K.T., Kim, S.J., Ha, H. Biochem. J. (2002) [Pubmed]

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AgaP_AGAP002118	Anopheles gambiae str. PEST
FZF	Arabidopsis thaliana
AT4G31420	Arabidopsis thaliana
ZNF622	Bos taurus
C16A3.4	Caenorhabditis elegans
ZNF622	Canis lupus familiaris
znf622	Danio rerio
CG6769	Drosophila melanogaster
ZNF622	Gallus gallus
ZNF622	Macaca mulatta
Zfp622	Mus musculus
Os06g0693500	Oryza sativa Japonica Group
ZNF622	Pan troglodytes
Zfp622	Rattus norvegicus
znf622	Xenopus (Silurana) tropicalis

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