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Gene Review

PHF20  -  PHD finger protein 20

Homo sapiens

Synonyms: C20orf104, GLEA2, Glioma-expressed antigen 2, HCA58, Hepatocellular carcinoma-associated antigen 58, ...
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Disease relevance of PHF20


Psychiatry related information on PHF20


High impact information on PHF20


Biological context of PHF20


Anatomical context of PHF20

  • A cDNA clone encoding a novel zinc finger protein expressed in lymphoid cells has been isolated [12].
  • Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product [13].
  • Our findings suggest that the novel zinc finger protein TIZ may play a role during osteoclast differentiation by modulating TRAF6 signaling activity [14].
  • We conclude that the novel zinc finger protein Zfp289, which may represent the mammalian homologue of Gcs-1, is potentially an important mediator of the Id-1-induced proliferation pathway in mammary epithelial cells [15].
  • GLP-1: A novel zinc finger protein required in somatic cells of the gonad for germ cell development [16].

Associations of PHF20 with chemical compounds

  • Complexes of W(CO)(5) with neutral diatomic pnictogen ligands N(2), P(2), As(2), Sb(2), and Bi(2) and anionic Group 14 ligands Si(2) (2-), Ge(2) (2-), Sn(2) (2-), and Pb(2) (2-) coordinated in both side-on and end-on fashion have been optimized by using density functional theory at the BP86 level with valence sets of TZP quality [17].
  • 4SR, a novel zinc-finger protein with SR-repeats, is expressed during early development of Xenopus [18].
  • To estimate the importance of relativistic effects on the reaction mechanisms between Ru and CO2, the potential energy surfaces have been performed in the triplet and quintet electronic states using quasi-relativistic (Pauli), zero-order regularly approximated (ZORA), and nonrelativistic (NR) density functional theory (DFT) at the PW91/TZP level [19].
  • Density functional theory calculations (PW91/STO-TZP, including basis-set superposition error corrections) have been used to evaluate hydrogen bond energies of five- and six-coordinate heme-NO complexes with phenol and imidazole, chosen as models for distal pocket tyrosine and histidine residues [20].
  • Conversely, veneer-framework systems consisting of feldspathic glass veneers and tough zirconia-based frameworks (TZP/Cercon S and Inceram-Zirconia/Vita VM7) may exhibit lifetimes longer than 20 years if the bridge connector is properly designed [21].

Other interactions of PHF20


Analytical, diagnostic and therapeutic context of PHF20


  1. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. Wang, Y., Han, K.J., Pang, X.W., Vaughan, H.A., Qu, W., Dong, X.Y., Peng, J.R., Zhao, H.T., Rui, J.A., Leng, X.S., Cebon, J., Burgess, A.W., Chen, W.F. J. Immunol. (2002) [Pubmed]
  2. Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival. Pallasch, C.P., Struss, A.K., Munnia, A., König, J., Steudel, W.I., Fischer, U., Meese, E. Int. J. Cancer (2005) [Pubmed]
  3. Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls. Fischer, U., Struss, A.K., Hemmer, D., Pallasch, C.P., Steudel, W.I., Meese, E. Clin. Exp. Immunol. (2001) [Pubmed]
  4. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Thiagalingam, A., De Bustros, A., Borges, M., Jasti, R., Compton, D., Diamond, L., Mabry, M., Ball, D.W., Baylin, S.B., Nelkin, B.D. Mol. Cell. Biol. (1996) [Pubmed]
  5. Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q. Shibuya, K., Kudoh, J., Okui, M., Shimizu, N. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. Genes Dev. (2004) [Pubmed]
  7. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Dominski, Z., Erkmann, J.A., Yang, X., Sànchez, R., Marzluff, W.F. Genes Dev. (2002) [Pubmed]
  8. Ubiquitin interactions of NZF zinc fingers. Alam, S.L., Sun, J., Payne, M., Welch, B.D., Blake, B.K., Davis, D.R., Meyer, H.H., Emr, S.D., Sundquist, W.I. EMBO J. (2004) [Pubmed]
  9. Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. Yun, J., Lee, W.H. Mol. Cell. Biol. (2003) [Pubmed]
  10. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. Attar, R.M., Gilman, M.Z. Mol. Cell. Biol. (1992) [Pubmed]
  11. trans repression of the human metallothionein IIA gene promoter by PZ120, a novel 120-kilodalton zinc finger protein. Tang, C.M., Westling, J., Seto, E. Mol. Cell. Biol. (1999) [Pubmed]
  12. Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines. Wu, B.Y., Hanley, E.W., Turka, L.A., Nabel, G.J. Blood (1992) [Pubmed]
  13. Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product. Nakamura, T., Yamazaki, Y., Saiki, Y., Moriyama, M., Largaespada, D.A., Jenkins, N.A., Copeland, N.G. Mol. Cell. Biol. (2000) [Pubmed]
  14. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. Shin, J.N., Kim, I., Lee, J.S., Koh, G.Y., Lee, Z.H., Kim, H.H. J. Biol. Chem. (2002) [Pubmed]
  15. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. Singh, J., Itahana, Y., Parrinello, S., Murata, K., Desprez, P.Y. J. Biol. Chem. (2001) [Pubmed]
  16. GLP-1: A novel zinc finger protein required in somatic cells of the gonad for germ cell development. Li, S., Lu, M.M., Zhou, D., Hammes, S.R., Morrisey, E.E. Dev. Biol. (2007) [Pubmed]
  17. Comparison of side-on and end-on coordination of E2 ligands in complexes [W(CO)5E2] (E=N, P, As, Sb, Bi, Si-, Ge-, Sn-, Pb-). Esterhuysen, C., Frenking, G. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  18. 4SR, a novel zinc-finger protein with SR-repeats, is expressed during early development of Xenopus. Ladomery, M., Marshall, R., Arif, L., Sommerville, J. Gene (2000) [Pubmed]
  19. Relativistic DFT study on the reaction mechanism of second-row transition metal Ru with CO2. Chen, X.Y., Zhao, Y.X., Wang, S.G. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
  20. Toward modeling H-NOX domains: a DFT study of heme-NO complexes as hydrogen bond acceptors. Tangen, E., Svadberg, A., Ghosh, A. Inorganic chemistry. (2005) [Pubmed]
  21. Cyclic fatigue in water of veneer-framework composites for all-ceramic dental bridges. Studart, A.R., Filser, F., Kocher, P., Lüthy, H., Gauckler, L.J. Dental materials : official publication of the Academy of Dental Materials (2007) [Pubmed]
  22. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. Sekimata, M., Homma, Y. Nucleic Acids Res. (2004) [Pubmed]
  23. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. Seong, H.A., Kim, K.T., Ha, H. J. Biol. Chem. (2003) [Pubmed]
  24. Molecular cloning and characterization of FX3, a novel zinc-finger protein. Xu, F., Wang, Y., Hall, F.L. Oncol. Rep. (2000) [Pubmed]
  25. Effect of different beta-lactams in combination with beta-lactamase inhibitors in the presence or absence of tobramycin against some enterobacteriaceae producing extended-spectrum beta-lactamases. Ferrara, A., Dos Santos, C., Cimbro, M. Chemotherapy. (1998) [Pubmed]
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