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Gene Review:

CLDN12 - claudin 12

Homo sapiens

Synonyms: Claudin-12

B??langer, M. et al.

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Disease relevance of CLDN12

Furthermore, claudin-12 down-regulation suggests that hyperammonemia may also affect tight junction integrity [1].

High impact information on CLDN12

Exposure to ammonia (5mM for 72h) resulted in significant increases in mRNA levels of taurine transporter (TAUT; 2.0-fold increase) as well as creatine transporter (CRT; 1.9-fold increase) whereas claudin-12 mRNA expression was significantly reduced to 67.7% of control levels [1].
Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro [1].

References

Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. B??langer, M., Asashima, T., Ohtsuki, S., Yamaguchi, H., Ito, S., Terasaki, T. Neurochem. Int. (2007) [Pubmed]

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