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Chemical Compound Review

tauphon     2-aminoethanesulfonic acid

Synonyms: Taurinum, Taukard, Taurina, taurine, taufon, ...
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Disease relevance of taurine


Psychiatry related information on taurine


High impact information on taurine


Chemical compound and disease context of taurine


Biological context of taurine


Anatomical context of taurine


Associations of taurine with other chemical compounds

  • In this issue of Neuron, Young and Cepko show that taurine acts via GlyRalpha2 subunit-containing glycine receptors expressed by retinal progenitor cells at birth [24].
  • However, since 3% methionine changed plasma taurine without altering BBMV uptake, it is more likely that the change in BBMV uptake and the adaptive response expressed at the brush border surface relate to changes in renal cortex taurine concentrations [21].
  • Moreover, naloxone (2 mg/kg), the specific opiate antagonist, increased blood pressure in taurine-treated DOCA-salt rats, restoring it to levels similar to those in the DOCA-salt rats [12].
  • In contrast, neither STa nor guanylin changed the uptake of taurine in HT-29 cells [13].
  • The modulation by taurine of taumustine activity suggests that the combination of these agents offers an advantage of selectivity and host protection during chemotherapy [14].

Gene context of taurine


Analytical, diagnostic and therapeutic context of taurine


  1. Decreased myocardial taurine levels and hypertaurinuria in a kindred with mitral-valve prolapse and congestive cardiomyopathy. Darsee, J.R., Heymsfield, S.B. N. Engl. J. Med. (1981) [Pubmed]
  2. Retinal degeneration associated with taurine deficiency in the cat. Hayes, K.C., Carey, R.E., Schmidt, S.Y. Science (1975) [Pubmed]
  3. Adrenergic stimulation of taurine transport by the heart. Huxtable, R., Chubb, J. Science (1977) [Pubmed]
  4. Cerebrospinal fluid taurine in Alzheimer's disease. Alom, J., Mahy, J.N., Brandi, N., Tolosa, E. Ann. Neurol. (1991) [Pubmed]
  5. Regulation of aldose reductase, sorbitol dehydrogenase, and taurine cotransporter mRNA in rat medulla. Martial, S., Price, S.R., Sands, J.M. J. Am. Soc. Nephrol. (1995) [Pubmed]
  6. Taurine-induced regeneration of goldfish retina in culture may involve a calcium-mediated mechanism. Lima, L., Matus, P., Drujan, B. J. Neurochem. (1993) [Pubmed]
  7. Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats. Li, F., Abatan, O.I., Kim, H., Burnett, D., Larkin, D., Obrosova, I.G., Stevens, M.J. Neurobiol. Dis. (2006) [Pubmed]
  8. gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. Do, K.Q., Lauer, C.J., Schreiber, W., Zollinger, M., Gutteck-Amsler, U., Cuénod, M., Holsboer, F. J. Neurochem. (1995) [Pubmed]
  9. Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Hogema, B.M., Gupta, M., Senephansiri, H., Burlingame, T.G., Taylor, M., Jakobs, C., Schutgens, R.B., Froestl, W., Snead, O.C., Diaz-Arrastia, R., Bottiglieri, T., Grompe, M., Gibson, K.M. Nat. Genet. (2001) [Pubmed]
  10. Nutritional requirement for taurine in patients receiving long-term parenteral nutrition. Geggel, H.S., Ament, M.E., Heckenlively, J.R., Martin, D.A., Kopple, J.D. N. Engl. J. Med. (1985) [Pubmed]
  11. Retraction. Darsee JR, Heymsfield SB. Decreased myocardial taurine levels and hypertaurinuria in a kindred with mitral-valve prolapse and congestive cardiomyopathy. N Engl J Med 1981;304:129-35. Heymsfield, S.B., Glenn, J.F. N. Engl. J. Med. (1983) [Pubmed]
  12. Hypotensive effect of taurine. Possible involvement of the sympathetic nervous system and endogenous opiates. Fujita, T., Sato, Y. J. Clin. Invest. (1988) [Pubmed]
  13. Regulation of taurine transport by Escherichia coli heat-stable enterotoxin and guanylin in human intestinal cell lines. Brandsch, M., Ramamoorthy, S., Marczin, N., Catravas, J.D., Leibach, J.W., Ganapathy, V., Leibach, F.H. J. Clin. Invest. (1995) [Pubmed]
  14. Modulation by taurine of the toxicity of taumustine, a compound with antitumor activity. Pierson, H.F., Fisher, J.M., Rabinovitz, M. J. Natl. Cancer Inst. (1985) [Pubmed]
  15. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Yoon, Y.B., Hagey, L.R., Hofmann, A.F., Gurantz, D., Michelotti, E.L., Steinbach, J.H. Gastroenterology (1986) [Pubmed]
  16. Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Podda, M., Ghezzi, C., Battezzati, P.M., Crosignani, A., Zuin, M., Roda, A. Gastroenterology (1990) [Pubmed]
  17. Unitary anion currents through phospholemman channel molecules. Moorman, J.R., Ackerman, S.J., Kowdley, G.C., Griffin, M.P., Mounsey, J.P., Chen, Z., Cala, S.E., O'Brian, J.J., Szabo, G., Jones, L.R. Nature (1995) [Pubmed]
  18. Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Pion, P.D., Kittleson, M.D., Rogers, Q.R., Morris, J.G. Science (1987) [Pubmed]
  19. Taurine: possible role in osmotic regulation of mammalian heart. Thurston, J.H., Hauhart, R.E., Naccarato, E.F. Science (1981) [Pubmed]
  20. Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. Chesney, R.W., Scriver, C.R., Mohyuddin, F. J. Clin. Invest. (1976) [Pubmed]
  21. Renal cortex taurine content regulates renal adaptive response to altered dietary intake of sulfur amino acids. Chesney, R.W., Gusowski, N., Dabbagh, S. J. Clin. Invest. (1985) [Pubmed]
  22. A role for ligand-gated ion channels in rod photoreceptor development. Young, T.L., Cepko, C.L. Neuron (2004) [Pubmed]
  23. Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. Weiss, S.J., Klein, R., Slivka, A., Wei, M. J. Clin. Invest. (1982) [Pubmed]
  24. Need rods? Get glycine receptors and taurine. Rentería, R.C., Johnson, J., Copenhagen, D.R. Neuron (2004) [Pubmed]
  25. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Mennone, A., Soroka, C.J., Cai, S.Y., Harry, K., Adachi, M., Hagey, L., Schuetz, J.D., Boyer, J.L. Hepatology (2006) [Pubmed]
  26. High affinity transport of taurine by the Drosophila aspartate transporter dEAAT2. Besson, M.T., Ré, D.B., Moulin, M., Birman, S. J. Biol. Chem. (2005) [Pubmed]
  27. Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice. Ferdinandusse, S., Denis, S., Overmars, H., Van Eeckhoudt, L., Van Veldhoven, P.P., Duran, M., Wanders, R.J., Baes, M. J. Biol. Chem. (2005) [Pubmed]
  28. Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]. Liu, Q.R., López-Corcuera, B., Mandiyan, S., Nelson, H., Nelson, N. J. Biol. Chem. (1993) [Pubmed]
  29. Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli. Eichhorn, E., van der Ploeg, J.R., Kertesz, M.A., Leisinger, T. J. Biol. Chem. (1997) [Pubmed]
  30. Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit. Cohen, B.I., Hofmann, A.F., Mosbach, E.H., Stenger, R.J., Rothschild, M.A., Hagey, L.R., Yoon, Y.B. Gastroenterology (1986) [Pubmed]
  31. Defective bile acid amidation: predicted features of a new inborn error of metabolism. Hofmann, A.F., Strandvik, B. Lancet (1988) [Pubmed]
  32. Hepatic taurine concentration and dietary taurine as regulators of bile acid conjugation with taurine. Hardison, W.G. Gastroenterology (1978) [Pubmed]
  33. Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation. Schmieden, V., Kuhse, J., Betz, H. EMBO J. (1992) [Pubmed]
  34. Taurine in the mammalian cerebellum: demonstration by autoradiography with [3H]taurine and immunocytochemistry with antibodies against the taurine-synthesizing enzyme, cysteine-sulfinic acid decarboxylase. Chan-Palay, V., Lin, C.T., Palay, S., Yamamoto, M., Wu, J.Y. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
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