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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

USP10  -  ubiquitin specific peptidase 10

Homo sapiens

Synonyms: Deubiquitinating enzyme 10, KIAA0190, UBPO, Ubiquitin carboxyl-terminal hydrolase 10, Ubiquitin thioesterase 10, ...
 
 
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Disease relevance of USP10

 

High impact information on USP10

  • The USP10/G3BP complex appears to co-immunoprecipitate with ubiquitinated species that could be substrates of USP10 [2].
  • In summary, the data indicate that USP10 is a new cofactor that binds to the AR and stimulates the androgen response of target promoters [3].
 

Other interactions of USP10

  • This interaction was further confirmed by performing a 2HS with G3BP, which led to the isolation of USP10 encoding cDNAs [2].
  • The ubiquitin-specific protease USP10 modulates androgen receptor function [3].
  • The combination of RTQ-LDA and RTQ identified thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10), and survivin as significantly over-expressed (P </= 0.050) in DOD compared to LTS patients [1].
 

Analytical, diagnostic and therapeutic context of USP10

  • CONCLUSIONS: Taken collectively, TS, USP10, survivin and RRM2 may be useful as prognostic indicators and/or in the development of rationally designed treatment protocols [1].

References

  1. Increased Expression of Thymidylate Synthetase (TS), Ubiquitin Specific Protease 10 (USP10) and Survivin is Associated with Poor Survival in Glioblastoma Multiforme (GBM). Grunda, J.M., Nabors, L.B., Palmer, C.A., Chhieng, D.C., Steg, A., Mikkelsen, T., Diasio, R.B., Zhang, K., Allison, D., Grizzle, W.E., Wang, W., Gillespie, G.Y., Johnson, M.R. J. Neurooncol. (2006) [Pubmed]
  2. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Soncini, C., Berdo, I., Draetta, G. Oncogene (2001) [Pubmed]
  3. The ubiquitin-specific protease USP10 modulates androgen receptor function. Faus, H., Meyer, H.A., Huber, M., Bahr, I., Haendler, B. Mol. Cell. Endocrinol. (2005) [Pubmed]
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