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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GNS  -  class 1 transmembrane glycoprotein

Bovine ephemeral fever virus

 
 
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Disease relevance of GNS

 

High impact information on GNS

  • Less abundant mRNAs which appeared to initiate at consensus sequences immediately preceding and following the GNS ORF and terminate at the same polyadenylation signal were also detected [3].
  • The second ORF encodes a polypeptide of 609 residues with nine potential glycosylation sites which is most closely related to the BEFV non-structural glycoprotein (GNS) [3].
 

Analytical, diagnostic and therapeutic context of GNS

  • Multiple sequence alignments and phylogenetic analyses indicated that the ARV G and GNS glycoproteins, like those of BEFV, are structurally related and appear to have evolved at different rates from a common ancestral gene [3].

References

  1. The genome of bovine ephemeral fever rhabdovirus contains two related glycoprotein genes. Walker, P.J., Byrne, K.A., Riding, G.A., Cowley, J.A., Wang, Y., McWilliam, S. Virology (1992) [Pubmed]
  2. Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus. McWilliam, S.M., Kongsuwan, K., Cowley, J.A., Byrne, K.A., Walker, P.J. J. Gen. Virol. (1997) [Pubmed]
  3. Adelaide river rhabdovirus expresses consecutive glycoprotein genes as polycistronic mRNAs: new evidence of gene duplication as an evolutionary process. Wang, Y., Walker, P.J. Virology (1993) [Pubmed]
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