The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sexual Development

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sexual Development


Psychiatry related information on Sexual Development


High impact information on Sexual Development


Chemical compound and disease context of Sexual Development


Biological context of Sexual Development


Anatomical context of Sexual Development


Associations of Sexual Development with chemical compounds


Gene context of Sexual Development

  • Because Bmpr1a is evolutionarily conserved, these findings indicate that a component of the BMP signaling pathway has been co-opted during evolution for male sexual development in amniotes [8].
  • Such evidence is highly suggestive of a conserved role(s) for Dmrt1 in vertebrate sexual development, but there has been no functional analysis of this gene in any species [32].
  • 3. We previously identified DMRT1, a human gene with sequence similarity to genes that regulate the sexual development of nematodes and insects [33].
  • intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation [34].
  • Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior [35].

Analytical, diagnostic and therapeutic context of Sexual Development


  1. Virilizing hepatoblastoma: precocious sexual development and partial response of pulmonary metastases to cis-platinum. Arshad, R.R., Woo, S.Y., Abbassi, V., Hoy, G.R., Sinks, L.F. CA: a cancer journal for clinicians. (1982) [Pubmed]
  2. Targeting transforming growth factor alpha expression to discrete loci of the neuroendocrine brain induces female sexual precocity. Rage, F., Hill, D.F., Sena-Esteves, M., Breakefield, X.O., Coffey, R.J., Costa, M.E., McCann, S.M., Ojeda, S.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome. Batch, J.A., Williams, D.M., Davies, H.R., Brown, B.D., Evans, B.A., Hughes, I.A., Patterson, M.N. Hum. Mol. Genet. (1992) [Pubmed]
  4. Growth and sexual development before and after sex steroid therapy in patients with thalassemia major. Landau, H., Gross, V., Dagan, I., Palti, Z., Rachmilewitz, E.A., Spitz, I.M. Arch. Intern. Med. (1984) [Pubmed]
  5. An immunoassay to detect human müllerian inhibiting substance in males and females during normal development. Hudson, P.L., Dougas, I., Donahoe, P.K., Cate, R.L., Epstein, J., Pepinsky, R.B., MacLaughlin, D.T. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  6. Characteristics of the androgenization produced in mice by neonatal exposure to alpha-fetoprotein antibodies. Mizejewski, G.J., Vonnegut, M. Teratology (1982) [Pubmed]
  7. The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein. Beye, M., Hasselmann, M., Fondrk, M.K., Page, R.E., Omholt, S.W. Cell (2003) [Pubmed]
  8. Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Jamin, S.P., Arango, N.A., Mishina, Y., Hanks, M.C., Behringer, R.R. Nat. Genet. (2002) [Pubmed]
  9. Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Nachtigal, M.W., Hirokawa, Y., Enyeart-VanHouten, D.L., Flanagan, J.N., Hammer, G.D., Ingraham, H.A. Cell (1998) [Pubmed]
  10. A nonmammalian homolog of the PAF1 gene (Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina. Berteaux-Lecellier, V., Picard, M., Thompson-Coffe, C., Zickler, D., Panvier-Adoutte, A., Simonet, J.M. Cell (1995) [Pubmed]
  11. Müllerian-inhibiting substance function during mammalian sexual development. Behringer, R.R., Finegold, M.J., Cate, R.L. Cell (1994) [Pubmed]
  12. Hypogonadotropic hypogonadism. Hayes, F.J., Seminara, S.B., Crowley, W.F. Endocrinol. Metab. Clin. North Am. (1998) [Pubmed]
  13. Endocrine disruption caused by two common pollutants at "acceptable" concentrations. Magliulo, L., Schreibman, M.P., Cepriano, J., Ling, J. Neurotoxicology and teratology. (2002) [Pubmed]
  14. Androgenic and estrogenic effects of the synthetic androgen 17alpha-methyltestosterone on sexual development and reproductive performance in the fathead minnow (Pimephales promelas) determined using the gonadal recrudescence assay. Pawlowski, S., Sauer, A., Shears, J.A., Tyler, C.R., Braunbeck, T. Aquat. Toxicol. (2004) [Pubmed]
  15. Male gonadal denervation by guanethidine at pre-puberty: different doses, different results. The intervention of the pineal deafferentation. Guimarães, M.A., Lunardi, L.O., Pellizzon, C.H., Kempinas, W.G., Rosa e Silva, A.A. Cell. Mol. Biol. (Noisy-le-grand) (1997) [Pubmed]
  16. Influence of fetal sex on the concentration of amniotic fluid testosterone: antenatal sex determination? Künzig, H.J., Meyer, U., Schmitz-Roeckerath, B., Broer, K.H. Archiv für Gynäkologie. (1977) [Pubmed]
  17. Evidence from mosaic analysis of the masculinizing gene her-1 for cell interactions in C. elegans sex determination. Hunter, C.P., Wood, W.B. Nature (1992) [Pubmed]
  18. The Drosophila female-specific sex-determination gene, Sex-lethal, has stage-, tissue-, and sex-specific RNAs suggesting multiple modes of regulation. Salz, H.K., Maine, E.M., Keyes, L.N., Samuels, M.E., Cline, T.W., Schedl, P. Genes Dev. (1989) [Pubmed]
  19. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. Obara-Ishihara, T., Okayama, H. EMBO J. (1994) [Pubmed]
  20. Divergent cAMP signaling pathways regulate growth and pathogenesis in the rice blast fungus Magnaporthe grisea. Adachi, K., Hamer, J.E. Plant Cell (1998) [Pubmed]
  21. Cell differentiation during sexual development of the fungus Sordaria macrospora requires ATP citrate lyase activity. Nowrousian, M., Masloff, S., Pöggeler, S., Kück, U. Mol. Cell. Biol. (1999) [Pubmed]
  22. Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Grimmond, S., Van Hateren, N., Siggers, P., Arkell, R., Larder, R., Soares, M.B., de Fatima Bonaldo, M., Smith, L., Tymowska-Lalanne, Z., Wells, C., Greenfield, A. Hum. Mol. Genet. (2000) [Pubmed]
  23. Mammary tumor induction by N-methyl-N-nitrosourea in genetically resistant Copenhagen rats. Lu, S.J., Laroye, G., Archer, M.C. Cancer Res. (1992) [Pubmed]
  24. Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms. Yi, W., Zarkower, D. Development (1999) [Pubmed]
  25. Region-specific regulation of transforming growth factor alpha (TGF alpha) gene expression in astrocytes of the neuroendocrine brain. Ma, Y.J., Berg-von der Emde, K., Moholt-Siebert, M., Hill, D.F., Ojeda, S.R. J. Neurosci. (1994) [Pubmed]
  26. Studies on human sexual development. V. Concentrations of testosterone, 17-hydroxyprogesterone and progesterone in human amniotic fluid throughout gestation. Warne, G.L., Faiman, C., Reyes, F.I., Winter, J.S. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  27. Neonatal progesterone and feminine sexual development. Shapiro, B.H., Goldman, A.S., Bongiovanni, A.M., Marino, J.M. Nature (1976) [Pubmed]
  28. Use of a potent, long acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty. Boepple, P.A., Mansfield, M.J., Wierman, M.E., Rudlin, C.R., Bode, H.H., Crigler, J.F., Crawford, J.D., Crowley, W.F. Endocr. Rev. (1986) [Pubmed]
  29. The combination of dissimilar alleles of the A alpha and A beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus. Kües, U., Richardson, W.V., Tymon, A.M., Mutasa, E.S., Göttgens, B., Gaubatz, S., Gregoriades, A., Casselton, L.A. Genes Dev. (1992) [Pubmed]
  30. Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia: a randomized controlled trial. Stein, E.A., Illingworth, D.R., Kwiterovich, P.O., Liacouras, C.A., Siimes, M.A., Jacobson, M.S., Brewster, T.G., Hopkins, P., Davidson, M., Graham, K., Arensman, F., Knopp, R.H., DuJovne, C., Williams, C.L., Isaacsohn, J.L., Jacobsen, C.A., Laskarzewski, P.M., Ames, S., Gormley, G.J. JAMA (1999) [Pubmed]
  31. A single nucleotide substitution introduces a premature termination codon into the androgen receptor gene of a patient with receptor-negative androgen resistance. Marcelli, M., Tilley, W.D., Wilson, C.M., Wilson, J.D., Griffin, J.E., McPhaul, M.J. J. Clin. Invest. (1990) [Pubmed]
  32. Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Raymond, C.S., Murphy, M.W., O'Sullivan, M.G., Bardwell, V.J., Zarkower, D. Genes Dev. (2000) [Pubmed]
  33. A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. Raymond, C.S., Parker, E.D., Kettlewell, J.R., Brown, L.G., Page, D.C., Kusz, K., Jaruzelska, J., Reinberg, Y., Flejter, W.L., Bardwell, V.J., Hirsch, B., Zarkower, D. Hum. Mol. Genet. (1999) [Pubmed]
  34. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Garrett-Engele, C.M., Siegal, M.L., Manoli, D.S., Williams, B.C., Li, H., Baker, B.S. Development (2002) [Pubmed]
  35. Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior. Yi, W., Ross, J.M., Zarkower, D. Development (2000) [Pubmed]
  36. Black-white contrasts in insulin levels during pubertal development. The Bogalusa Heart Study. Svec, F., Nastasi, K., Hilton, C., Bao, W., Srinivasan, S.R., Berenson, G.S. Diabetes (1992) [Pubmed]
  37. The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process. Palmert, M.R., Hayden, D.L., Mansfield, M.J., Crigler, J.F., Crowley, W.F., Chandler, D.W., Boepple, P.A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  38. Psychological aspects of the Canadian randomized controlled trial of human growth hormone and low-dose ethinyl oestradiol in children with Turner syndrome. The Canadian Growth Hormone Advisory Group. Rovet, J., Holland, J. Horm. Res. (1993) [Pubmed]
  39. Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Ashby, J., Tinwell, H., Lefevre, P.A., Odum, J., Paton, D., Millward, S.W., Tittensor, S., Brooks, A.N. Regulatory toxicology and pharmacology : RTP. (1997) [Pubmed]
  40. Frontal-executive dysfunction in early onset cerebellar ataxia of Holmes' type. Vielhaber, S., Ebert, A.D., Feistner, H., Herrmann, M. Clinical neurology and neurosurgery. (2000) [Pubmed]
WikiGenes - Universities