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Gene Review:

ECs4685 - AsnC family transcriptional regulator

Escherichia coli O157:H7 str. Sakai

Kölling, R. et al., Willins, D.A. et al., Kudo , N. et al., Yokoyama, K. et al., Thaw, P. et al.

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Disease relevance of ECs4685

Feast/famine regulatory proteins (FFRPs): Escherichia coli Lrp, AsnC and related archaeal transcription factors [1].

High impact information on ECs4685

Lrp has some amino acid sequence similarity to AsnC, a protein that regulates asnA expression (Kolling, R., and Lother, H. (1985) J. Bacteriol. 164, 310-315) [2].
The expression of the gidA gene which is located immediately counterclockwise of the replication origin of Escherichia coli, oriC, was found to be negatively regulated by the AsnC protein in an in vitro transcription-translation system [3].
Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding [4].

Analytical, diagnostic and therapeutic context of ECs4685

Crystallization and secondary-structure determination of a protein of the Lrp/AsnC family from a hyperthermophilic archaeon [5].

References

Feast/famine regulatory proteins (FFRPs): Escherichia coli Lrp, AsnC and related archaeal transcription factors. Yokoyama, K., Ishijima, S.A., Clowney, L., Koike, H., Aramaki, H., Tanaka, C., Makino, K., Suzuki, M. FEMS Microbiol. Rev. (2006) [Pubmed]
Characterization of Lrp, and Escherichia coli regulatory protein that mediates a global response to leucine. Willins, D.A., Ryan, C.W., Platko, J.V., Calvo, J.M. J. Biol. Chem. (1991) [Pubmed]
AsnC, a multifunctional regulator of genes located around the replication origin of Escherichia coli, oriC. Kölling, R., Gielow, A., Seufert, W., Kücherer, C., Messer, W. Mol. Gen. Genet. (1988) [Pubmed]
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family. Thaw, P., Sedelnikova, S.E., Muranova, T., Wiese, S., Ayora, S., Alonso, J.C., Brinkman, A.B., Akerboom, J., van der Oost, J., Rafferty, J.B. Nucleic Acids Res. (2006) [Pubmed]
Crystallization and secondary-structure determination of a protein of the Lrp/AsnC family from a hyperthermophilic archaeon. Kudo , N., Allen , M.D., Koike , H., Katsuya , Y., Suzuki , M. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]

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