High impact information on FIBP

• Acidic fibroblast growth factor (aFGF) intracellular binding protein (FIBP) is a protein found mainly in the nucleus that might be involved in the intracellular function of aFGF [1].
• Here we present a comparative analysis of the deduced amino acid sequences of human, murine and Drosophila FIBP analogues and demonstrate that FIBP is an evolutionarily conserved protein [1].
• Reverse transcriptase polymerase chain reaction analysis of FIBP mRNA from Drosophila revealed differential splicing by intron retention resulting in the production of three distinct FIBP transcripts [2].

Anatomical context of FIBP

• FIBP became post-translationally associated with microsomes added to the cell-free protein synthesizing system, and the membrane-associated protein bound aFGF with high efficiency [3].

Associations of FIBP with chemical compounds

• In vitro-translated FIBP bound specifically to a fusion protein of maltose-binding protein and aFGF [3].

Other interactions of FIBP

• The possibility is discussed that FIBP may be involved in the mitogenic action of aFGF [3].

Analytical, diagnostic and therapeutic context of FIBP

• Using comparative sequence analysis of Drosophila and human FIBP genes we demonstrate a remarkable conservation of their structural architecture suggesting that FIBP from vertebrates and insects are genuine homologues [2].

References