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Gene Review:

NEXN - nexilin (F actin binding protein)

Homo sapiens

Synonyms: CMH20, F-actin-binding protein, NELIN, Nelin, Nexilin, ...

Wang, W. et al., Shen, L. et al.

Shen, Zhang, Sheng, Wang,

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High impact information on NEXN

Stable transfection of NELIN into HeLa cells increased the cell migration by 2.17-fold and the adhesion by 1.67-fold, respectively, compared to cells with the empty vector (P<0.05) [1].
The results support that NELIN product is an F-actin associated protein and mediates cell motility [1].
NELIN was expressed primarily in the heart and skeletal muscle among eight tested normal tissues [1].
The gene shares high similarity to the gene encoding F-actin binding protein nexilin, so named as NELIN [1].

Anatomical context of NEXN

NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion [1].

Analytical, diagnostic and therapeutic context of NEXN

Immunofluorescence and immunoprecipitation demonstrated that NELIN product was associated with F-actin [1].
The title binuclear complex, [CuFe(CN)(5)(C(8)H(21)N(5)O(2))(NO)] x 2H(2)O or [CuFe(nelin)(CN)(5)(NO)] x 2H(2)O (nelin is 5-methyl-5-nitro-3,7-diazanonane-1,9-diamine) consists of discrete binuclear mixed-metal species, with a Cu centre linked to an Fe centre through a cyano bridge, and two water molecules of crystallization [2].

References

NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion. Wang, W., Zhang, W., Han, Y., Chen, J., Wang, Y., Zhang, Z., Hui, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
u-Cyano-1:2 kappa(2)C:N-tetracyano-1 kappa(4)C-(5-methyl-5-nitro-3,7-diazanonane-1,9-diamine-2 kappa(4)N(1,3,6,9))-nitrosyl-1 kappa N-copper(II)iron(II) dihydrate. Shen, L., Zhang, Y.J., Sheng, G.D., Wang, H.T. Acta crystallographica. Section C, Crystal structure communications. (2002) [Pubmed]

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