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Gene Review:

ECs0853 - biotin synthase

Escherichia coli O157:H7 str. Sakai

Ohsawa, I. et al., Eisenberg, M.A. et al., Cohen, G. et al.

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Disease relevance of ECs0853

Cloning of the biotin synthetase gene from Bacillus sphaericus and expression in Escherichia coli and Bacilli [1].

High impact information on ECs0853

Derepression was not due to any direct regulatory effect of the antibiotics but was the consequence of the inhibition of the biotin synthetase enzyme; this inhibition prevented the intracellular concentration of biotin from reaching the levels required for normal regulation of the biotin A operon [2].
Biotin synthetase (BS) catalyses the biotransformation of dethiobiotin (DTB) to biotin [1].
Comparison of the amino acid sequences of BS from E. coli and B. sphaericus revealed extensive similarity [1].
Clones carrying ColE1 amp-bio plasmids produce elevated levels of biotin and biotin synthetase activity [3].

References

Cloning of the biotin synthetase gene from Bacillus sphaericus and expression in Escherichia coli and Bacilli. Ohsawa, I., Speck, D., Kisou, T., Hayakawa, K., Zinsius, M., Gloeckler, R., Lemoine, Y., Kamogawa, K. Gene (1989) [Pubmed]
Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin. Eisenberg, M.A., Hsiung, S.C. Antimicrob. Agents Chemother. (1982) [Pubmed]
Isolation and characterization of a ColE1 plasmid containing the entire bio gene cluster of Escherichia coli K12. Cohen, G., Zimmer, Z., Gurevich, R., Yankofsky, S. Mol. Gen. Genet. (1978) [Pubmed]

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