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Chemical Compound Review

dethiobiotin     6-(5-methyl-2-oxo- imidazolidin-4...

Synonyms: Desthiobiotin, AGN-PC-00IWQ4, SureCN143997, NSC-3085, AG-E-06180, ...
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Disease relevance of dl-Dithiobiotin


High impact information on dl-Dithiobiotin


Chemical compound and disease context of dl-Dithiobiotin


Biological context of dl-Dithiobiotin


Anatomical context of dl-Dithiobiotin


Associations of dl-Dithiobiotin with other chemical compounds


Gene context of dl-Dithiobiotin


Analytical, diagnostic and therapeutic context of dl-Dithiobiotin

  • The first two steps of dethiobiotin formation, which is a complex, multistep enzymatic reaction, have been elucidated by a combination of X-ray crystallography and kinetic methods [22].


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  8. Further investigation on the turnover of Escherichia coli biotin synthase with dethiobiotin and 9-mercaptodethiobiotin as substrates. Tse Sum Bui, B., Lotierzo, M., Escalettes, F., Florentin, D., Marquet, A. Biochemistry (2004) [Pubmed]
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  14. Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells. Rodriguez-Melendez, R., Lewis, B., McMahon, R.J., Zempleni, J. J. Nutr. (2003) [Pubmed]
  15. Biotin synthase contains two distinct iron-sulfur cluster binding sites: chemical and spectroelectrochemical analysis of iron-sulfur cluster interconversions. Ugulava, N.B., Gibney, B.R., Jarrett, J.T. Biochemistry (2001) [Pubmed]
  16. Dethiobiotin synthetase: the carbonylation of 7,8-diaminonanoic acid proceeds regiospecifically via the N7-carbamate. Gibson, K.J., Lorimer, G.H., Rendina, A.R., Taylor, W.S., Cohen, G., Gatenby, A.A., Payne, W.G., Roe, D.C., Lockett, B.A., Nudelman, A. Biochemistry (1995) [Pubmed]
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  18. Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. Ramanathan, S., Pooyan, S., Stein, S., Prasad, P.D., Wang, J., Leibowitz, M.J., Ganapathy, V., Sinko, P.J. Pharm. Res. (2001) [Pubmed]
  19. Genetic analysis of an incomplete bio operon in a biotin auxotrophic strain of Bacillus subtilis natto OK2. Sasaki, M., Kawamura, F., Kurusu, Y. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  20. Biotin synthesis in higher plants: purification and characterization of bioB gene product equivalent from Arabidopsis thaliana overexpressed in Escherichia coli and its subcellular localization in pea leaf cells. Baldet, P., Alban, C., Douce, R. FEBS Lett. (1997) [Pubmed]
  21. Flavodoxin is required for conversion of dethiobiotin to biotin in Escherichia coli. Ifuku, O., Koga, N., Haze, S., Kishimoto, J., Wachi, Y. Eur. J. Biochem. (1994) [Pubmed]
  22. Substrate binding and carboxylation by dethiobiotin synthetase--a kinetic and X-ray study. Alexeev, D., Baxter, R.L., Smekal, O., Sawyer, L. Structure (1995) [Pubmed]
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