High impact information on ZMYM5

• Formalin-fixed, paraffin-embedded tissue sections of 251 biopsies from 97 patients with BM were immunostained with the anti-Glut1 antibody MYM, after microwave-aided antigen retrieval, using the standard avidin-biotin complex immunoperoxidase technique [1].
• Data from electrophoretic mobility shift assays indicate that ERM and possibly ZNF237 interact with a fragment of the PS1 promoter [2].
• Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM [2].
• It is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing, including a large 382 amino acid form containing a single MYM domain, and 2 shorter forms of 208 and 213 amino acids respectively that do not [2].
• ZNF237 maps to 13q11-->q12, immediately proximal to ZNF198 [3].

Biological context of ZMYM5

• Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11-->q12 [3].

Analytical, diagnostic and therapeutic context of ZMYM5

• Two alternatively spliced regions were identified by RT-PCR; the major splice variant is predicted to encode a 383 amino acid protein that contains a single diverged MYM domain [3].

References