Gene Review:
ZMYM2 - zinc finger, MYM-type 2
Homo sapiens
Synonyms:
FIM, Fused in myeloproliferative disorders protein, MYM, RAMP, Rearranged in atypical myeloproliferative disorder protein, ...
- FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Xiao, S., Nalabolu, S.R., Aster, J.C., Ma, J., Abruzzo, L., Jaffe, E.S., Stone, R., Weissman, S.M., Hudson, T.J., Fletcher, J.A. Nat. Genet. (1998)
- The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13. Still, I.H., Cowell, J.K. Blood (1998)
- A case of myelofibrosis with a t(4;13)(q25;q12): evidence for involvement of a second 13q12 locus in chronic myeloproliferative disorders. MacDonald, D.H., Lahiri, D., Chase, A., Sohal, J., Goldman, J.M., Cross, N.C. Br. J. Haematol. (1999)
- Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). Popovici, C., Adélaïde, J., Ollendorff, V., Chaffanet, M., Guasch, G., Jacrot, M., Leroux, D., Birnbaum, D., Pébusque, M.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Impact of osteoarthritis on rehabilitation for persons with hip fracture. Nguyen-Oghalai, T.U., Ottenbacher, K.J., Granger, C.V., Smith, S.T., Goodwin, J.S. Arthritis Rheum. (2006)
- The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Raffa, G.D., Cenci, G., Siriaco, G., Goldberg, M.L., Gatti, M. Mol. Cell (2005)
- The costs of the detrimental effects of alcohol abuse have grown faster than alcohol consumption in Finland. Salomaa, J. Addiction (1995)
- The minimally conscious state and recovery potential: a follow-up study 2 to 5 years after traumatic brain injury. Lammi, M.H., Smith, V.H., Tate, R.L., Taylor, C.M. Archives of physical medicine and rehabilitation. (2005)
- Adverse effects of depression and cognitive impairment on rehabilitation participation and recovery from hip fracture. Lenze, E.J., Munin, M.C., Dew, M.A., Rogers, J.C., Seligman, K., Mulsant, B.H., Reynolds, C.F. International journal of geriatric psychiatry. (2004)
- Functional outcomes from inpatient rehabilitation after traumatic brain injury: how do hispanics fare? Arango-Lasprilla, J.C., Rosenthal, M., Deluca, J., Cifu, D.X., Hanks, R., Komaroff, E. Archives of physical medicine and rehabilitation (2007)
- PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Chen, J., Deangelo, D.J., Kutok, J.L., Williams, I.R., Lee, B.H., Wadleigh, M., Duclos, N., Cohen, S., Adelsperger, J., Okabe, R., Coburn, A., Galinsky, I., Huntly, B., Cohen, P.S., Meyer, T., Fabbro, D., Roesel, J., Banerji, L., Griffin, J.D., Xiao, S., Fletcher, J.A., Stone, R.M., Gilliland, D.G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase that is involved in atypical myeloproliferative disease. Kasyapa, C.S., Kunapuli, P., Hawthorn, L., Cowell, J.K. Blood (2006)
- The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins. Demiroglu, A., Steer, E.J., Heath, C., Taylor, K., Bentley, M., Allen, S.L., Koduru, P., Brody, J.P., Hawson, G., Rodwell, R., Doody, M.L., Carnicero, F., Reiter, A., Goldman, J.M., Melo, J.V., Cross, N.C. Blood (2001)
- Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. Younes, M., Lechago, L.V., Lechago, J. Clin. Cancer Res. (1996)
- Tizanidine for the treatment of intention myoclonus: a case series. Mukand, J.A., Giunti, E.J. Archives of physical medicine and rehabilitation. (2004)
- Midodrine for the management of orthostatic hypotension in patients with spinal cord injury: A case report. Mukand, J., Karlin, L., Barrs, K., Lublin, P. Archives of physical medicine and rehabilitation. (2001)
- Can forced-use therapy be clinically applied after stroke? An exploratory randomized controlled trial. Ploughman, M., Corbett, D. Archives of physical medicine and rehabilitation. (2004)
- Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Reiter, A., Sohal, J., Kulkarni, S., Chase, A., Macdonald, D.H., Aguiar, R.C., Gonçalves, C., Hernandez, J.M., Jennings, B.A., Goldman, J.M., Cross, N.C. Blood (1998)
- The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome. Kulkarni, S., Reiter, A., Smedley, D., Goldman, J.M., Cross, N.C. Genomics (1999)
- ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins. Kunapuli, P., Somerville, R., Still, I.H., Cowell, J.K. Oncogene (2003)
- ANF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5. Smedley, D., Demiroglu, A., Abdul-Rauf, M., Heath, C., Cooper, C., Shipley, J., Cross, N.C. Neoplasia (1999)
- Patients with stroke confined to basal ganglia have diminished response to rehabilitation efforts. Miyai, I., Blau, A.D., Reding, M.J., Volpe, B.T. Neurology (1997)
- Storage and release of mechanical energy by contracting frog muscle fibres. Cavagna, G.A., Heglund, N.C., Harry, J.D., Mantovani, M. J. Physiol. (Lond.) (1994)
- Hierarchical linear modeling of FIM instrument growth curve characteristics after spinal cord injury. Warschausky, S., Kay, J.B., Kewman, D.G. Archives of physical medicine and rehabilitation. (2001)
- Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation. Wetzler, M., Brady, M.T., Tracy, E., Li, Z.R., Donohue, K.A., O'loughlin, K.L., Cheng, Y., Mortazavi, A., McDonald, A.A., Kunapuli, P., Wallace, P.K., Baer, M.R., Cowell, J.K., Baumann, H. Clin. Cancer Res. (2006)
- Rifampin plus trimethoprim: bactericidal activity and suppression of resistance in human urine in vitro. Goldstein, B.P., Ripamonti, I.F., Bolzoni, G., Carniti, G., Arioli, V. Antimicrob. Agents Chemother. (1979)
- 5-fluorouracil, ifosfamide and mitomycin (FIM) combination for pancreatic-biliary tumors. Abad, A., Rosell, R., Barnadas, A., Carles, J., Ribelles, N., Solano, V. Ann. Oncol. (1991)
- The costs of intense neuromuscular block for anesthesia during endolaryngeal procedures due to waiting time. Puura, A.I., Rorarius, M.G., Manninen, P., Hopput, S., Baer, G.A. Anesth. Analg. (1999)
- Decreased heart rate recovery after exercise in patients with congestive heart failure: effect of beta-blocker therapy. Racine, N., Blanchet, M., Ducharme, A., Marquis, J., Boucher, J.M., Juneau, M., White, M. J. Card. Fail. (2003)
- Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Inoue, H., Nobuhisa, I., Okita, K., Takizawa, M., Pébusque, M.J., Taga, T. Biochem. Biophys. Res. Commun. (2004)
- The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors. Baumann, H., Kunapuli, P., Tracy, E., Cowell, J.K. J. Biol. Chem. (2003)
- ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML. Kunapuli, P., Kasyapa, C.S., Chin, S.F., Caldas, C., Cowell, J.K. Exp. Cell Res. (2006)
- Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease. Kasyapa, C.S., Kunapuli, P., Cowell, J.K. Exp. Cell Res. (2005)