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Gene Review

dnapol  -  ORF58

Epiphyas postvittana nucleopolyhedrovirus

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Disease relevance of dnapol

  • While less protein was obtained from the E. coli expression system, SpliNPV DNAPOL purified from E. coli displayed similar biochemical characteristics to DNAPOL expressed in, and subsequently purified from, insect cells (Sf9) using a baculovirus expression system [1].

High impact information on dnapol

  • To reconcile the conflicting data and determine if the AcMNPV DNA polymerase is required for viral DNA replication during the course of an infection, a dnapol-null virus was generated using bacmid technology [2].
  • 3' RACE demonstrated that the SpliNPV dnapol transcript terminated at the polyadenylation signal AATAAA [3].

Analytical, diagnostic and therapeutic context of dnapol


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