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Gene Review

DLGAP2  -  discs, large (Drosophila) homolog...

Homo sapiens

Synonyms: DAP-2, DAP2, Disks large-associated protein 2, PSD-95/SAP90-binding protein 2, SAP90/PSD-95-associated protein 2, ...
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Psychiatry related information on DLGAP2


High impact information on DLGAP2

  • Sequence comparisons of human DLGAP2 cDNA sequences obtained from human testis and brain cDNA libraries with homologous rat genes suggest alternative splicing in the 5' end of the gene [1].
  • Using DAP-1 primer sequences a second cDNA (DAP-2) was subsequently isolated from decidual RNA by reverse transcription (RT)-PCR and found to be identical to DAP-1 apart from 80 additional and consecutive base pairs in the N-terminal coding region [2].
  • In DAP-2, a stop codon within the unique 80 bp sequence was predicted to terminate translation immediately before the consensus active site residues [2].

Anatomical context of DLGAP2

  • The 5' coding sequence of the testis cDNA is complete, whereas based on homology with the rat gene 103 bp of coding sequence may still be missing in the 5' end of the DLGAP2 brain transcript [1].


  1. Positional cloning and characterisation of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation. Ranta, S., Zhang, Y., Ross, B., Takkunen, E., Hirvasniemi, A., de la Chapelle, A., Gilliam, T.C., Lehesjoki, A.E. Eur. J. Hum. Genet. (2000) [Pubmed]
  2. Alternative forms of a novel aspartyl protease gene are differentially expressed in human gestational tissues. Moses, E.K., Freed, K.A., Higgins, J.R., Brennecke, S.P. Mol. Hum. Reprod. (1999) [Pubmed]
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