High impact information on TIMM50

• Tim50 is anchored to the inner mitochondrial membrane, exposing the C-terminal domain to the intermembrane space [1].
• Functional defects of Tim50 either by depletion of the protein or addition of anti-Tim50 antibodies block the protein translocation across the inner membrane [1].
• Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death [2].
• RESULTS: In this report, we identify a minor isoform of the mitochondrial Tim50, Tim50a, as a coilin interacting protein [3].
• Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis [3].

Anatomical context of TIMM50

• These observations indicate that loss of Tim50 in vertebrates causes mitochondrial membrane permeabilization and dysfunction followed by cytoplasmic release of cytochrome c along with other mitochondrial inducers of cell death [2].
• In contrast to Tim50, which localizes to the cytoplasm and mitochondria, Tim50a is strictly nuclear and is enriched in speckles with snRNPs [3].

References