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Gene Review

COIL  -  coilin

Homo sapiens

Synonyms: CLN80, Coilin, p80-coilin
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Disease relevance of COIL


High impact information on COIL

  • The relative risk associated with use of a Dalkon Shield was 6.8 (1.8 to 25.2), and that associated with use of either a Lippes Loop or Saf-T Coil IUD was 3.2 (0.9 to 12.0) [6].
  • An epitope was present in this COOH-terminal 14-kD region, which was recognized by 18 of 20 sera with anti-p80 reactivity, and affinity-purified antibody from the recombinant protein also reacted in immunofluorescence to show specific staining of the coiled body [7].
  • We used fluorescence recovery after photobleaching (FRAP) on isolated Xenopus oocyte nuclei to measure the steady-state exchange rate between the nucleoplasm and CBs of three fluorescently tagged molecules: U7 small nuclear RNA, coilin, and TATA-binding protein (TBP) [8].
  • The methylation inhibitor 5'-deoxy-5'-methylthioadenosine reduces the levels of coilin methylation and causes the appearance of SMN-positive gems [9].
  • Here we report that the Cajal body is a major epitope in HeLa cells for an sDMA-specific antibody and that coilin is an sDMA-containing protein as analyzed by using the sDMA-specific antibody and matrix-assisted laser desorption ionization time of flight mass spectrometry [9].

Biological context of COIL


Anatomical context of COIL


Associations of COIL with chemical compounds

  • Treatment of cells with inhibitors of either CDKs (olomoucine, 200 microM) or RNA polymerase I (actinomycin D, 0.05 microgram/ml), results in a striking reorganization of CDK2 and p80 coilin to the nucleolar periphery [10].
  • Mutation of a single serine residue in p80 coilin to aspartate (S202D) also causes coiled bodies and splicing snRNPs to localize within nucleoli when the mutant is transiently transfected and expressed in HeLa cells [17].
  • A polyclonal rabbit antiserum (R288) raised against recombinant p80-coilin was shown to have similar immunochemical properties as human autoantibodies and was used to analyze the expression of p80-coilin-associated CBs in cell cultures synchronized by double thymidine block, nocodazole arrest, serum starvation, or hormonal deprivation [18].
  • In addition, the accumulation of JA-regulated Pin1 transcripts after aphid feeding was Coil dependent [19].
  • Experimental phase diagrams (A form, B form, Coil) were built in the coordinates (a, alcohol fraction: T, temperature) for the natural DNAs and poly d(A-T) [20].

Physical interactions of COIL

  • Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus [21].
  • We suggest that an important function of coilin is to form a transient complex with the U7 snRNP and accompany it to the CBs [22].

Enzymatic interactions of COIL


Co-localisations of COIL

  • However, we observed that CGI-55 localizes to the nucleolus and co-localizes with p80-coilin positive nuclear-coiled bodies [23].

Regulatory relationships of COIL

  • snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN [24].

Other interactions of COIL


Analytical, diagnostic and therapeutic context of COIL


  1. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. Xu, H., Somers, Z.B., Robinson, M.L., Hebert, M.D. BMC Cell Biol. (2005) [Pubmed]
  2. Coiled bodies in the nucleolus of breast cancer cells. Ochs, R.L., Stein, T.W., Tan, E.M. J. Cell. Sci. (1994) [Pubmed]
  3. Doppler flow evaluation can anticipate abnormal left lung perfusion after transcatheter closure of patent ductus arteriosus. Soares, A.M., Aiello, V.D., Andrade, J.L., Kajita, L.J., Soares, J., Morhy, S.S., Mathias, W., Lopes, A.A., Ramires, J.A. Eur. Heart J. (2004) [Pubmed]
  4. Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma. Ek, O., Waurzyniak, B., Myers, D.E., Uckun, F.M. Clin. Cancer Res. (1998) [Pubmed]
  5. Endovascular treatment of ruptured intracranial aneurysms with detachable coils: long-term clinical and serial angiographic results. Sluzewski, M., van Rooij, W.J., Rinkel, G.J., Wijnalda, D. Radiology. (2003) [Pubmed]
  6. Primary tubal infertility in relation to the use of an intrauterine device. Daling, J.R., Weiss, N.S., Metch, B.J., Chow, W.H., Soderstrom, R.M., Moore, D.E., Spadoni, L.R., Stadel, B.V. N. Engl. J. Med. (1985) [Pubmed]
  7. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. Andrade, L.E., Chan, E.K., Raska, I., Peebles, C.L., Roos, G., Tan, E.M. J. Exp. Med. (1991) [Pubmed]
  8. Steady-state dynamics of Cajal body components in the Xenopus germinal vesicle. Handwerger, K.E., Murphy, C., Gall, J.G. J. Cell Biol. (2003) [Pubmed]
  9. Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. Boisvert, F.M., Cote, J., Boulanger, M.C., Cleroux, P., Bachand, F., Autexier, C., Richard, S. J. Cell Biol. (2002) [Pubmed]
  10. Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies. Liu, J., Hebert, M.D., Ye, Y., Templeton, D.J., Kung, H., Matera, A.G. J. Cell. Sci. (2000) [Pubmed]
  11. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. Xu, H., Hebert, M.D. BMC Cell Biol. (2005) [Pubmed]
  12. Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus. Bohmann, K., Ferreira, J.A., Lamond, A.I. J. Cell Biol. (1995) [Pubmed]
  13. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure. Carmo-Fonseca, M., Ferreira, J., Lamond, A.I. J. Cell Biol. (1993) [Pubmed]
  14. p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product. Hong, S., Ka, S., Kim, S., Park, Y., Kang, S. Biochim. Biophys. Acta (2003) [Pubmed]
  15. Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles. Parfenov, V.N., Davis, D.S., Pochukalina, G.N., Kostyuchek, D., Murti, K.G. J. Cell. Biochem. (1998) [Pubmed]
  16. Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo. Sleeman, J.E., Trinkle-Mulcahy, L., Prescott, A.R., Ogg, S.C., Lamond, A.I. J. Cell. Sci. (2003) [Pubmed]
  17. Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus. Lyon, C.E., Bohmann, K., Sleeman, J., Lamond, A.I. Exp. Cell Res. (1997) [Pubmed]
  18. Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation. Andrade, L.E., Tan, E.M., Chan, E.K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Coil-dependent signaling pathway is not required for Mi-1-mediated potato aphid resistance. Bhattarai, K.K., Xie, Q.G., Pourshalimi, D., Younglove, T., Kaloshian, I. Mol. Plant Microbe Interact. (2007) [Pubmed]
  20. Three-state diagram for DNA. Ivanov, V.I., Krylov DYu, n.u.l.l., Minyat, E.E. J. Biomol. Struct. Dyn. (1985) [Pubmed]
  21. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. Santama, N., Ogg, S.C., Malekkou, A., Zographos, S.E., Weis, K., Lamond, A.I. J. Biol. Chem. (2005) [Pubmed]
  22. Coilin can form a complex with the U7 small nuclear ribonucleoprotein. Bellini, M., Gall, J.G. Mol. Biol. Cell (1998) [Pubmed]
  23. CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus. Lemos, T.A., Kobarg, J. Cell Biochem. Biophys. (2006) [Pubmed]
  24. snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN. Sleeman, J.E., Ajuh, P., Lamond, A.I. J. Cell. Sci. (2001) [Pubmed]
  25. Nopp140 functions as a molecular link between the nucleolus and the coiled bodies. Isaac, C., Yang, Y., Meier, U.T. J. Cell Biol. (1998) [Pubmed]
  26. Colocalization of intranuclear lamin foci with RNA splicing factors. Jagatheesan, G., Thanumalayan, S., Muralikrishna, B., Rangaraj, N., Karande, A.A., Parnaik, V.K. J. Cell. Sci. (1999) [Pubmed]
  27. Interactions between coilin and PIASy partially link Cajal bodies to PML bodies. Sun, J., Xu, H., Subramony, S.H., Hebert, M.D. J. Cell. Sci. (2005) [Pubmed]
  28. Structure, expression and chromosomal localization of human p80-coilin gene. Chan, E.K., Takano, S., Andrade, L.E., Hamel, J.C., Matera, A.G. Nucleic Acids Res. (1994) [Pubmed]
  29. Assignment of a human autoimmune antigen, p80-coilin gene to chromosome 17q21-q23 and of its possible pseudogene to chromosome 14. Kusuda, J., Tanuma, R., Gotoh, E., Toyoda, A., Hashimoto, K. Hum. Genet. (1995) [Pubmed]
  30. Microinjection of anti-coilin antibodies affects the structure of coiled bodies. Almeida, F., Saffrich, R., Ansorge, W., Carmo-Fonseca, M. J. Cell Biol. (1998) [Pubmed]
  31. Human p80-coilin is targeted to sphere organelles in the amphibian germinal vesicle. Wu, Z., Murphy, C., Gall, J.G. Mol. Biol. Cell (1994) [Pubmed]
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