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Gene Review

B5R  -  B5R

Monkeypox virus Zaire-96-I-16

 
 
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Disease relevance of B5R

  • However, B5R-deficient vaccinia virus showed a normal localization pattern for other EEV envelope proteins [1].
  • LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox [2].
  • The ps/hr gene (B5R open reading frame homolog) of rabbitpox virus controls pock color, is a component of extracellular enveloped virus, and is secreted into the medium [3].
  • A rabbit antiserum was raised to the predicted external hydrophilic domain of B5R expressed in Escherichia coli and used to immunoprecipitate a M(r) 42 K protein from vaccinia-infected cells [4].
  • The construction and isolation of recombinants of vaccinia virus (IHD-J strain), bearing on their outer membrane a chimeric protein consisting of the cytoplasmic and transmembrane domains of vaccinia B5R protein and the external domain of HIV envelope, has been previously described by us [5].
 

High impact information on B5R

  • The ability of the highly attenuated vaccinia virus vaccine strain LC16m8, with a mutation in the important immunogenic membrane protein B5R, to induce protective immunity against monkeypox in nonhuman primates was evaluated in comparison with the parental Lister strain [2].
  • The B5R open reading frame (ORF) encodes a membrane protein that is essential for EEV formation [6].
  • Moreover, vdeltaA36R IEV labelled with EGFP fused to the B5R protein co-localized with microtubules, showing that the A36R protein is not required for the interaction of IEV with microtubules [7].
  • Three of these palmitylproteins are encoded by the A33R, B5R, and F13L open reading frames and migrate by gel electrophoresis with relative molecular masses of 23-28, 42, and 37 kDa, respectively [8].
  • The B5R gene encodes an EEV-specific type I membrane protein, and deletion of this gene markedly decreases EEV formation and results in a small plaque phenotype [9].

References

  1. Intracellular localization of vaccinia virus extracellular enveloped virus envelope proteins individually expressed using a Semliki Forest virus replicon. Lorenzo, M.M., Galindo, I., Griffiths, G., Blasco, R. J. Virol. (2000) [Pubmed]
  2. LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox. Saijo, M., Ami, Y., Suzaki, Y., Nagata, N., Iwata, N., Hasegawa, H., Ogata, M., Fukushi, S., Mizutani, T., Sata, T., Kurata, T., Kurane, I., Morikawa, S. J. Virol. (2006) [Pubmed]
  3. The ps/hr gene (B5R open reading frame homolog) of rabbitpox virus controls pock color, is a component of extracellular enveloped virus, and is secreted into the medium. Martinez-Pomares, L., Stern, R.J., Moyer, R.W. J. Virol. (1993) [Pubmed]
  4. A constitutively expressed vaccinia gene encodes a 42-kDa glycoprotein related to complement control factors that forms part of the extracellular virus envelope. Engelstad, M., Howard, S.T., Smith, G.L. Virology (1992) [Pubmed]
  5. Ultraviolet-irradiated vaccinia virus recombinants, exposing HIV-envelope on their outer membrane, induce antibodies against this antigen in rabbits. Loewinger, M., Katz, E. Viral Immunol. (2002) [Pubmed]
  6. Functional analysis of vaccinia virus B5R protein: essential role in virus envelopment is independent of a large portion of the extracellular domain. Herrera, E., Lorenzo, M.M., Blasco, R., Isaacs, S.N. J. Virol. (1998) [Pubmed]
  7. Vaccinia virus intracellular enveloped virions move to the cell periphery on microtubules in the absence of the A36R protein. Herrero-Martínez, E., Roberts, K.L., Hollinshead, M., Smith, G.L. J. Gen. Virol. (2005) [Pubmed]
  8. Identification and analysis of vaccinia virus palmitylproteins. Grosenbach, D.W., Hansen, S.G., Hruby, D.E. Virology (2000) [Pubmed]
  9. Functional analysis of vaccinia virus B5R protein: role of the cytoplasmic tail. Lorenzo, M.M., Herrera, E., Blasco, R., Isaacs, S.N. Virology (1998) [Pubmed]
 
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