Disease relevance of Monkeypox

• Cidofovir has proven effective against vaccinia, cowpox and monkeypox in various animal model infections [1].
• Cidofovir thus holds great promise for treating human smallpox, monkeypox, and other poxvirus infections [2].
• Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses [3].
• The nucleotide sequences of 1275 bp in the TK gene region of variola and monkeypox viruses have been determined [4].
• There is much interest in cidofovir as a potential treatment for smallpox, monkeypox and other orthopoxvirus infections [5].

High impact information on Monkeypox

• Here, we demonstrate that rhesus macaques vaccinated with a DNA vaccine consisting of four vaccinia virus genes (L1R, A27L, A33R, and B5R) were protected from severe disease after an otherwise lethal challenge with monkeypox virus [6].
• In the Orthopoxvirus assay, consensus Orthopoxvirus PCR primers were designed to amplify 266-281 base-pair (bp) segments of the hemagglutinin (HA) gene in camelpox, cowpox, monkeypox, and vaccinia viruses [7].
• The two MAbs could distinguish between the sera of monkeypox patients and those of vaccinated persons [8].
• Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox) [9].
• Such efforts manifested benefits during the SARS outbreaks and monkeypox cases of 2003 [10].

References