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MeSH Review

Vaccinia Virus

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Disease relevance of Vaccinia Virus

  • The cowpox virus (CPV) CrmA and the equivalent rabbitpox virus (RPV) SPI-2 proteins have anti-inflammatory and antiapoptosis activity by virtue of their ability to inhibit caspases, including the interleukin-1beta-converting enzyme (ICE; caspase-1) [1].
  • However, swinepox virus and vaccinia virus (strain WR) do not express this activity Using a recombinant poxviruses, the myxoma M-T1 and rabbitpox virus 35kDa secreted proteins were identified as prototypic members of this family of chemokine binding proteins [2].

High impact information on Vaccinia Virus


Chemical compound and disease context of Vaccinia Virus


Gene context of Vaccinia Virus

  • Attenuation of B5R mutants of rabbitpox virus in vivo is related to impaired growth and not an enhanced host inflammatory response [9].
  • A new approach is reported that includes multiple-peptide synthesis and CD spectroscopy of overlapping peptides to evaluate the secondary structure of the vaccinia-virus thymidine kinase (TK) [10].

Analytical, diagnostic and therapeutic context of Vaccinia Virus


  1. Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. Macen, J., Takahashi, A., Moon, K.B., Nathaniel, R., Turner, P.C., Moyer, R.W. J. Virol. (1998) [Pubmed]
  2. The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues. Graham, K.A., Lalani, A.S., Macen, J.L., Ness, T.L., Barry, M., Liu, L.Y., Lucas, A., Clark-Lewis, I., Moyer, R.W., McFadden, G. Virology (1997) [Pubmed]
  3. Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication. Luttge, B.G., Moyer, R.W. J. Virol. (2005) [Pubmed]
  4. SPI-1-dependent host range of rabbitpox virus and complex formation with cathepsin G is associated with serpin motifs. Moon, K.B., Turner, P.C., Moyer, R.W. J. Virol. (1999) [Pubmed]
  5. The ps/hr gene (B5R open reading frame homolog) of rabbitpox virus controls pock color, is a component of extracellular enveloped virus, and is secreted into the medium. Martinez-Pomares, L., Stern, R.J., Moyer, R.W. J. Virol. (1993) [Pubmed]
  6. Microarray analysis of A549 cells infected with rabbitpox virus (RPV): a comparison of wild-type RPV and RPV deleted for the host range gene, SPI-1. Brum, L.M., Lopez, M.C., Varela, J.C., Baker, H.V., Moyer, R.W. Virology (2003) [Pubmed]
  7. Effect of isoleucine deprivation of rabbitpox virus DNA synthesis in mouse L cells. Murphy, M., Ley, K.D. J. Gen. Virol. (1975) [Pubmed]
  8. Plaque development by vaccinia-viruses on the chicken chorio-allantois under the influence of cyclophosphamide. Norpoth, K., Huth, M., Witting, U. Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. (1975) [Pubmed]
  9. Attenuation of B5R mutants of rabbitpox virus in vivo is related to impaired growth and not an enhanced host inflammatory response. Stern, R.J., Thompson, J.P., Moyer, R.W. Virology (1997) [Pubmed]
  10. Evaluation of the secondary structure of vaccinia-virus thymidine kinase by circular-dichroism spectroscopy of overlapping synthetic peptides. Behrends, H.W., Beck-Sickinger, A.G., Folkers, G. Eur. J. Biochem. (1996) [Pubmed]
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