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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SP_2190  -  choline binding protein A

Streptococcus pneumoniae TIGR4

 
 
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Disease relevance of SP_2190

 

High impact information on SP_2190

  • Several pneumococcal proteins including pneumococcal surface proteins A and C, hyaluronate lyase, pneumolysin, autolysin, pneumococcal surface antigen A, choline binding protein A, and two neuraminidase enzymes are being investigated as potential vaccine or drug targets [2].
  • High-, but not low-binding S. pneumoniae used Choline-binding protein A (CbpA) to bind to complement component C3 on epithelial cell surfaces [3].
 

Analytical, diagnostic and therapeutic context of SP_2190

  • The FH binding activity was finally localized to a 12-amino acid motif in the N-terminal CbpA by peptide mapping [4].
  • Immunofluorescence microscopy analysis showed that this region of CbpA is also necessary for FH deposition to the surface of the intact pneumococci [4].

References

  1. Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. Luo, R., Mann, B., Lewis, W.S., Rowe, A., Heath, R., Stewart, M.L., Hamburger, A.E., Sivakolundu, S., Lacy, E.R., Bjorkman, P.J., Tuomanen, E., Kriwacki, R.W. EMBO J. (2005) [Pubmed]
  2. Pneumococcal virulence factors: structure and function. Jedrzejas, M.J. Microbiol. Mol. Biol. Rev. (2001) [Pubmed]
  3. Differential activation of inflammatory pathways in A549 type II pneumocytes by Streptococcus pneumoniae strains with different adherence properties. Robson, R.L., Reed, N.A., Horvat, R.T. BMC Infect. Dis. (2006) [Pubmed]
  4. Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. Lu, L., Ma, Y., Zhang, J.R. J. Biol. Chem. (2006) [Pubmed]
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