The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

SP_2190  -  choline binding protein A

Streptococcus pneumoniae TIGR4

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SP_2190


High impact information on SP_2190

  • Several pneumococcal proteins including pneumococcal surface proteins A and C, hyaluronate lyase, pneumolysin, autolysin, pneumococcal surface antigen A, choline binding protein A, and two neuraminidase enzymes are being investigated as potential vaccine or drug targets [2].
  • High-, but not low-binding S. pneumoniae used Choline-binding protein A (CbpA) to bind to complement component C3 on epithelial cell surfaces [3].

Analytical, diagnostic and therapeutic context of SP_2190

  • The FH binding activity was finally localized to a 12-amino acid motif in the N-terminal CbpA by peptide mapping [4].
  • Immunofluorescence microscopy analysis showed that this region of CbpA is also necessary for FH deposition to the surface of the intact pneumococci [4].


  1. Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. Luo, R., Mann, B., Lewis, W.S., Rowe, A., Heath, R., Stewart, M.L., Hamburger, A.E., Sivakolundu, S., Lacy, E.R., Bjorkman, P.J., Tuomanen, E., Kriwacki, R.W. EMBO J. (2005) [Pubmed]
  2. Pneumococcal virulence factors: structure and function. Jedrzejas, M.J. Microbiol. Mol. Biol. Rev. (2001) [Pubmed]
  3. Differential activation of inflammatory pathways in A549 type II pneumocytes by Streptococcus pneumoniae strains with different adherence properties. Robson, R.L., Reed, N.A., Horvat, R.T. BMC Infect. Dis. (2006) [Pubmed]
  4. Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. Lu, L., Ma, Y., Zhang, J.R. J. Biol. Chem. (2006) [Pubmed]
WikiGenes - Universities