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Gene Review

PGAP3  -  post-GPI attachment to proteins 3

Homo sapiens

Synonyms: AGLA546, CAB2, COS16 homolog, Gene coamplified with ERBB2 protein, MGC9753, ...
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Disease relevance of PERLD1

  • Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers [1].

High impact information on PERLD1

  • A highly significant association between amplification and expression levels was observed for six of these genes, including ERBB2 and two uncharacterized hypothetical proteins, MGC9753 and MGC14832 [2].
  • Two ORFs were predicted within human MGC9753 mRNA, and ORF1 (nucleotide position 18-980 of NM_033419.1) was predicted as the coding region of human MGC9753 mRNA based on comparative genomics [3].
  • Nucleotide sequence of mouse Mgc9753 mRNA was next determined in silico by modification of AK052486 cDNA (deleting C at the nucleotide position 37) [3].
  • MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain [3].


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