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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PGAP3  -  post-GPI attachment to proteins 3

Homo sapiens

Synonyms: AGLA546, CAB2, COS16 homolog, Gene coamplified with ERBB2 protein, MGC9753, ...
 
 
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Disease relevance of PERLD1

  • Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers [1].
 

High impact information on PERLD1

  • A highly significant association between amplification and expression levels was observed for six of these genes, including ERBB2 and two uncharacterized hypothetical proteins, MGC9753 and MGC14832 [2].
  • Two ORFs were predicted within human MGC9753 mRNA, and ORF1 (nucleotide position 18-980 of NM_033419.1) was predicted as the coding region of human MGC9753 mRNA based on comparative genomics [3].
  • Nucleotide sequence of mouse Mgc9753 mRNA was next determined in silico by modification of AK052486 cDNA (deleting C at the nucleotide position 37) [3].
  • MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain [3].

References

  1. Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers. Nezu, M., Nishigaki, M., Ishizuka, T., Kuwahara, Y., Tanabe, C., Aoyagi, K., Sakamoto, H., Saito, Y., Yoshida, T., Sasaki, H., Terada, M. Jpn. J. Cancer Res. (2002) [Pubmed]
  2. Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer. Kauraniemi, P., Kuukasjärvi, T., Sauter, G., Kallioniemi, A. Am. J. Pathol. (2003) [Pubmed]
  3. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
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