Disease relevance of comD

• Here we report on the genetic variability of comC and comD within Streptococcus pneumoniae isolates [1].
• The histidine protein kinase SppK is a peptide pheromone-activated kinase that regulates the production of the bacteriocin sakacin P in Lactobacillus sakei [2].

High impact information on comD

• The trt mutation was localized to comD, the gene encoding the transmembrane histidine kinase [3].
• Two such non-PBP genes have been described: a putative glycosyltransferase, CpoA, and a histidine protein kinase, CiaH [4].
• A comC mutant did not exhibit any detectable CSP activity, while a comD mutant that contained an intact comC produced minimal CSP activity [5].
• Overlapping expression patterns for the genes cinA and comD (G. Alloing, B. Martin, C. Granadel, and J. P. Claverys, Mol. Microbiol. 29:75-83, 1998) suggest that at least two distinct regulatory mechanisms may underlie the competence cycle [6].
• The com operon of naturally transformable streptococcal species contains three genes, comC, comD, and comE, involved in the regulation of competence [1].

Anatomical context of comD

• The link between mutations in the histidine protein kinase CiaH and phenotypic expression of cefotaxime resistance suggests that the cell is able to monitor the integrity of the cell wall and in emergency cases such as during the action of beta-lactams can counteract such danger [7].

Other interactions of comD

• Null mutants with defects in either comC or comD were transformation deficient and failed to respond to exogenous CSP [5].

References