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Gene Review

EFTUD2  -  elongation factor Tu GTP binding domain...

Homo sapiens

Synonyms: 116 kDa U5 small nuclear ribonucleoprotein component, Elongation factor Tu GTP-binding domain-containing protein 2, KIAA0031, MFDGA, MFDM, ...
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High impact information on EFTUD2


Biological context of EFTUD2

  • These studies revealed multiple interactions between distinct domains of the U5 proteins hPrp8, hBrr2 (a DExH/D-box helicase), and hSnu114 (a putative GTPase), which are key players in the catalytic activation of the spliceosome, during which the U4/U6 base-pairing interaction is disrupted and U4 is released from the spliceosome [3].

Anatomical context of EFTUD2

  • Based on its homology with the ribosomal translocase EF-G, it is thought that GTP hydrolysis by Snu114 induces conformational rearrangements in the spliceosome [2].


  1. An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. Fabrizio, P., Laggerbauer, B., Lauber, J., Lane, W.S., Lührmann, R. EMBO J. (1997) [Pubmed]
  2. Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. Brenner, T.J., Guthrie, C. RNA (2006) [Pubmed]
  3. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. Liu, S., Rauhut, R., Vornlocher, H.P., Lührmann, R. RNA (2006) [Pubmed]
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