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Gene Review

SNU114  -  U5 snRNP GTPase SNU114

Saccharomyces cerevisiae S288c

Synonyms: 114 kDa U5 small nuclear ribonucleoprotein component, GIN10, Growth inhibitory protein 10, Pre-mRNA-splicing factor SNU114, YKL173W, ...
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High impact information on SNU114


Biological context of SNU114

  • We propose that GTP hydrolysis results in a rearrangement between Prp8 and the C terminus of Snu114 that leads to release of U1 and U4, thus activating the spliceosome for catalysis [4].
  • To assess the functional importance of the domains of Snu114, we used random mutagenesis to create conditionally lethal alleles [4].
  • An arginine residue in domain II, which in EF-G forms a salt bridge with a residue of the G domain, when mutated in Snu114p (R487E), led to a temperature-sensitive phenotype [3].

Anatomical context of SNU114

  • Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation [4].
  • To test whether Snu114p in the spliceosome is involved in rearranging RNA secondary structures (by analogy to EF-2 in the ribosome), we created conditionally lethal mutants [5].


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