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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ube2n  -  ubiquitin-conjugating enzyme E2N

Mus musculus

Synonyms: 1500026J17Rik, AL022654, BB101821, Bendless-like ubiquitin-conjugating enzyme, Blu, ...
 
 
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High impact information on Ube2n

  • The frequency of T lymphocytes was severely reduced in spleens from Ubc13-deficient mice [1].
  • In addition, PMA/ionophore-mediated ubiquitination of NF-kappaB essential modulator (NEMO)/IkappaB kinase gamma (IKKgamma) and phosphorylation of TGF-beta-activated kinase 1 (TAK1) were nearly abolished in Ubc13-deficient thymocytes [1].
  • Regarding the signal transduction, although NF-kappaB activation was modestly affected, PMA/ionophore-induced activation of Jnk and p38 was profoundly impaired in Ubc13-deficient thymocytes [1].
  • Endogenous gene (Ubc13 gene) expression in the liver was inhibited by 80% when Ubc13-siRNA complexed with galactosylated liposomes was administered to mice at a dose of 0.29nmol/g. In contrast, the bare cationic liposomes did not induce any silencing effect on Ubc13 gene expression [2].

References

  1. Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling. Yamamoto, M., Sato, S., Saitoh, T., Sakurai, H., Uematsu, S., Kawai, T., Ishii, K.J., Takeuchi, O., Akira, S. J. Immunol. (2006) [Pubmed]
  2. Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. Sato, A., Takagi, M., Shimamoto, A., Kawakami, S., Hashida, M. Biomaterials (2007) [Pubmed]
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