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Gene Review

B3galt5  -  UDP-Gal:betaGlcNAc beta 1,3...

Mus musculus

Synonyms: 1190002B21Rik, AU045265, B3gt5, Beta-1,3-GalTase 5, Beta-1,3-galactosyltransferase 5, ...
 
 
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Disease relevance of B3galt5

  • The SSEA-3 synthase activity of beta3GalT-V was confirmed in vivo by stable expression of the human beta3GalT-V gene in F9 mouse teratocarcinoma cells, as detected with the monoclonal antibody MC-631 by flow cytometry analysis and immunostaining of extracted glycolipids [1].
 

High impact information on B3galt5

  • beta1,3-Galactosyltransferase beta3Gal-T5 is highly expressed in the colons of humans and certain primates due to a retroviral long terminal repeat (LTR) acting as a strong promoter [2].
  • We identified three novel 5'-UTRs of beta3Gal-T5 mRNA, types A, B, and C, and found widespread expression of the type A transcript at much lower levels than the LTR transcript, the expression of which is restricted to organs of the gastrointestinal tract [2].

References

 
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