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Gene Review

B3GALT5  -  UDP-Gal:betaGlcNAc beta 1,3...

Homo sapiens

Synonyms: B3GalT-V, B3GalTx, B3T5, Beta-1,3-GalTase 5, Beta-1,3-galactosyltransferase 5, ...
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Disease relevance of B3GALT5


High impact information on B3GALT5


Biological context of B3GALT5


Anatomical context of B3GALT5


Associations of B3GALT5 with chemical compounds


Regulatory relationships of B3GALT5

  • Moreover, recombinant carcinoembryonic antigen purified from a CHO clone expressing Fuc-TIII and beta3Gal-T5 reacts with anti-sialyl-Lewis a and carries type 1 chains on oligosaccharides released by endo-beta-galactosidase [3].

Other interactions of B3GALT5

  • It could be demonstrated for the first time, by use of UDP-6-biotinyl-Gal as a donor substrate, that the human recombinant galactosyltransferases beta3Gal-T5, beta4Gal-T1, and beta4Gal-T4 mediate biotinylation of the neoglycoconjugate bovine serum albumin-p-aminophenyl N-acetyl-beta-D-glucosaminide (BSA-(GlcNAc)17) and ovalbumin [9].


  1. Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. Isshiki, S., Togayachi, A., Kudo, T., Nishihara, S., Watanabe, M., Kubota, T., Kitajima, M., Shiraishi, N., Sasaki, K., Andoh, T., Narimatsu, H. J. Biol. Chem. (1999) [Pubmed]
  2. Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5. Dunn, C.A., van de Lagemaat, L.N., Baillie, G.J., Mager, D.L. Gene (2005) [Pubmed]
  3. beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas. Salvini, R., Bardoni, A., Valli, M., Trinchera, M. J. Biol. Chem. (2001) [Pubmed]
  4. Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. Isshiki, S., Kudo, T., Nishihara, S., Ikehara, Y., Togayachi, A., Furuya, A., Shitara, K., Kubota, T., Watanabe, M., Kitajima, M., Narimatsu, H. J. Biol. Chem. (2003) [Pubmed]
  5. An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. Dunn, C.A., Medstrand, P., Mager, D.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. Kakiuchi, Y., Tsuji, S., Tsujii, M., Murata, H., Kawai, N., Yasumaru, M., Kimura, A., Komori, M., Irie, T., Miyoshi, E., Sasaki, Y., Hayashi, N., Kawano, S., Hori, M. Cancer Res. (2002) [Pubmed]
  7. Comparative Analysis of Retroviral and Native Promoters Driving Expression of beta1,3-Galactosyltransferase beta3Gal-T5 in Human and Mouse Tissues. Mare, L., Trinchera, M. J. Biol. Chem. (2007) [Pubmed]
  8. Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans. Mare, L., Trinchera, M. Eur. J. Biochem. (2004) [Pubmed]
  9. Chemoenzymatic synthesis of biotinylated nucleotide sugars as substrates for glycosyltransferases. Bülter, T., Schumacher, T., Namdjou, D.J., Gutiérrez Gallego, R., Clausen, H., Elling, L. Chembiochem (2001) [Pubmed]
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