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Gene Review:

Dpep1 - dipeptidase 1 (renal)

Rattus norvegicus

Synonyms: Dipeptidase 1, Microsomal dipeptidase, Rdp, Renal dipeptidase

Inamura, T. et al., Adachi, H. et al., McIntyre, T. et al., Kropp, H. et al.

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High impact information on Dpep1

Renal catabolism of glutathione. Characterization of a particulate rat renal dipeptidase that catalyzes the hydrolysis of cysteinylglycine [1].
Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase [2].
The antigen corresponding to renal dipeptidase was recognized in lung, liver, and testis [3].
In this study, rat renal dipeptidase (dehydropeptidase-I, microsomal dipeptidase; EC 3.4.13.11), which converts LTD4 to leukotriene E4 (LTE4) in kidney, was purified from rat kidney and the distribution of immunoreactive dipeptidase in multiple rat organs was determined [3].
COS-1 cells transfected with the cDNA expressed enzymatically active rrDP [4].

Biological context of Dpep1

Three cDNA clones of rat renal dipeptidase (rrDP) were isolated from rat renal and pulmonary cDNA libraries using a DNA fragment of human renal DP cDNA clone, MDP4, as a probe [4].

References

Renal catabolism of glutathione. Characterization of a particulate rat renal dipeptidase that catalyzes the hydrolysis of cysteinylglycine. McIntyre, T., Curthoys, N.P. J. Biol. Chem. (1982) [Pubmed]
Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase. Kropp, H., Sundelof, J.G., Hajdu, R., Kahan, F.M. Antimicrob. Agents Chemother. (1982) [Pubmed]
Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. Inamura, T., Pardridge, W.M., Kumagai, Y., Black, K.L. Prostaglandins Leukot. Essent. Fatty Acids (1994) [Pubmed]
Primary structure of rat renal dipeptidase and expression of its mRNA in rat tissues and COS-1 cells. Adachi, H., Ishida, N., Tsujimoto, M. Biochim. Biophys. Acta (1992) [Pubmed]

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DPEP1	Bos taurus
DPEP1	Canis lupus familiaris
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