The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DPEP1  -  dipeptidase 1 (renal)

Homo sapiens

Synonyms: Dehydropeptidase-I, Dipeptidase 1, MBD1, MDP, Microsomal dipeptidase, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DPEP1


Psychiatry related information on DPEP1

  • 48 patients with episodic psychosis (18 schizophrenia, 30 MDP) were studied to examine whether they had similar hallucinations in consecutive episodes [5].
  • We randomly selected 35 PD patients, 33 MDP patients, 27 MD patients and 30 normal volunteers with no family history of anxiety or mood disorder [6].
  • A total of 16 (45.7%) PD patients, 12 (36.4%) MDP patients, four (11.1%) MD patients, and two (6.7%) normal volunteers had a panic attack after hyperventilating [6].
  • Recent observations argue in favor of the presence of an MDP bacterial structure in mammalian mediators which increase slow-wave sleep and/or produce fever [7].
  • Treatment of cultured monocytes with the synthetic adjuvants N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and its lipophilic derivative, [B30]-MDP, did not significantly affect the D2V permissiveness of the cells [8].

High impact information on DPEP1

  • Here, we use an adoptive precursor cell transfer strategy into MP-depleted mice to establish the in vivo differentiation sequence from a recently identified MPhi/DC-restricted bone marrow (BM) precursor (MDP) via BM and blood intermediates to peripheral MPhis and DCs [9].
  • In this issue of Neuron, de Carvalho Aguiar and colleagues report the identification of missense mutations in the gene for the Na+/K+ -ATPase alpha3 subunit (ATP1A3) as a cause of rapid-onset dystonia-parkinsonism (RDP, DYT12) [10].
  • RESULTS: 18FDG PET detected more lesions than 99mTc MDP scintigraphy (mean, 14.1 and 7.8 lesions, respectively; P < .01) [2].
  • Expression of immunologically cross-reactive and enzymatically active MDP was attained in COS cells transfected with the cDNA [11].
  • Carbohydrate analyses of the purified human dipeptidase demonstrated that it was not a glycoprotein, a characteristic that distinguishes it from porcine and rat renal dipeptidase. beta-Lactamase activity of the purified human enzyme was demonstrated by measuring its activity against the two beta-lactam antibiotics, imipenem and SCH 29482 [12].

Chemical compound and disease context of DPEP1


Biological context of DPEP1


Anatomical context of DPEP1

  • Using cDNA micro-array screening, we found dipeptidase 1 (DPEP1) to be highly expressed in colon tumors compared to matched normal mucosa [1].
  • Renal dipeptidase (EC has been purified from human kidney cortex by affinity chromatography on cilastatin-Sepharose following solubilization with either n-octyl-beta-D-glucopyranoside or bacterial phosphatidylinositol-specific phospholipase C (PI-PLC) [19].
  • Membrane dipeptidase (MDP) is a zinc metalloenzyme located in the lungs and on the brush border membranes of the kidney and intestine [3].
  • In BRK cells transformed by the temperature-sensitive tsA58 mutant of SV40 T antigen, MDP activity was not detectable, in cell lines grown at the permissive temperature (33 degrees C) but after 5-14 days of incubation at the non-permissive temperature (39.5 degrees C), MDP protein and enzyme activity could be readily detected [3].
  • It was finally revealed that the migration of monocytes was enhanced by MDP [20].

Associations of DPEP1 with chemical compounds


Other interactions of DPEP1


Analytical, diagnostic and therapeutic context of DPEP1


  1. Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma. McIver, C.M., Lloyd, J.M., Hewett, P.J., Hardingham, J.E. Cancer Lett. (2004) [Pubmed]
  2. Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. Cook, G.J., Houston, S., Rubens, R., Maisey, M.N., Fogelman, I. J. Clin. Oncol. (1998) [Pubmed]
  3. Stable and temperature-sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase. Keynan, S., Asipu, A., Hooper, N.M., Turner, A.J., Blair, G.E. Oncogene (1997) [Pubmed]
  4. N-acetyl muramyl dipeptide stimulation of bone resorption in tissue culture. Dewhirst, F.E. Infect. Immun. (1982) [Pubmed]
  5. Recurrence of hallucinations in consecutive episodes of schizophrenia and affective disorder. Chaturvedi, S.K., Sinha, V.K. Schizophr. Res. (1990) [Pubmed]
  6. Hyperventilation challenge test in panic disorder and depression with panic attacks. Nardi, A.E., Valença, A.M., Nascimento, I., Zin, W.A. Psychiatry research. (2001) [Pubmed]
  7. Muramyl peptides as possible endogenous immunopharmacological mediators. Chedid, L. Microbiol. Immunol. (1983) [Pubmed]
  8. Dengue type 2 virus infection in human peripheral blood monocyte cultures. Hotta, H., Wiharta, A.S., Hotta, S., Homma, M. Microbiol. Immunol. (1984) [Pubmed]
  9. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. Varol, C., Landsman, L., Fogg, D.K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., Jung, S. J. Exp. Med. (2007) [Pubmed]
  10. Paying the price at the pump: dystonia from mutations in a Na+/K+ -ATPase. Cannon, S.C. Neuron (2004) [Pubmed]
  11. Primary structure of human microsomal dipeptidase deduced from molecular cloning. Adachi, H., Tawaragi, Y., Inuzuka, C., Kubota, I., Tsujimoto, M., Nishihara, T., Nakazato, H. J. Biol. Chem. (1990) [Pubmed]
  12. Beta-lactamase activity of purified and partially characterized human renal dipeptidase. Campbell, B.J., Forrester, L.J., Zahler, W.L., Burks, M. J. Biol. Chem. (1984) [Pubmed]
  13. Clinical evaluation of the immunoadjuvant murabutide, a derivative of MDP, administered with a tetanus toxoid vaccine. Telzak, E., Wolff, S.M., Dinarello, C.A., Conlon, T., el Kholy, A., Bahr, G.M., Choay, J.P., Morin, A., Chedid, L. J. Infect. Dis. (1986) [Pubmed]
  14. Effects of hyperthermia and muramyl dipeptide on IL-1beta, IL-6, and mortality in a neonatal rat model. Nelson, E.A., Wong, Y., Yu, L.M., Fok, T.F., Li, K. Pediatr. Res. (2002) [Pubmed]
  15. Uptake of technetium 99m MDP by hepatoblastoma. Cory, D.A., Siddiqui, A.R., Cohen, M.D. European journal of nuclear medicine. (1987) [Pubmed]
  16. A randomized study comparing clinical efficacy and safety of thienamycin formamidine (MK0787)/renal dipeptidase inhibitor (MK0791) and cefazolin. Ribner, B.S., Raeder, R., Hollstein, M., Freimer, E.H. J. Antimicrob. Chemother. (1983) [Pubmed]
  17. Physical and genetic mapping of the dipeptidase gene DPEP1 to 16q24.3. Austruy, E., Jeanpierre, C., Antignac, C., Whitmore, S.A., Van Cong, N., Bernheim, A., Callen, D.F., Junien, C. Genomics (1993) [Pubmed]
  18. Assignment of the human renal dipeptidase gene (DPEP1) to band q24 of chromosome 16. Nakagawa, H., Inazawa, J., Inoue, K., Misawa, S., Kashima, K., Adachi, H., Nakazato, H., Abe, T. Cytogenet. Cell Genet. (1992) [Pubmed]
  19. Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. Hooper, N.M., Keen, J.N., Turner, A.J. Biochem. J. (1990) [Pubmed]
  20. Stimulation of migration of human monocytes by bacterial cell walls and muramyl peptides. Ogawa, T., Kotani, S., Fukuda, K., Tsukamoto, Y., Mori, M., Kusumoto, S., Shiba, T. Infect. Immun. (1982) [Pubmed]
  21. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. Nitanai, Y., Satow, Y., Adachi, H., Tsujimoto, M. J. Mol. Biol. (2002) [Pubmed]
  22. Purification and characterization of human microsomal dipeptidase. Adachi, H., Kubota, I., Okamura, N., Iwata, H., Tsujimoto, M., Nakazato, H., Nishihara, T., Noguchi, T. J. Biochem. (1989) [Pubmed]
  23. Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide. Koga, T., Sakamoto, S., Onoue, K., Kotani, S., Sumiyoshi, A. Arthritis Rheum. (1980) [Pubmed]
  24. Absence of binding of MDP, a synthetic immunoadjuvant, to anti-peptidoglycan antibodies. Audibert, F., Heymer, B., Gros, C., Schleifer, K.H., Seidl, P.H., Chedid, L. J. Immunol. (1978) [Pubmed]
  25. Recent advances in the chemistry and biology of carbapenem antibiotics. Coulton, S., Hunt, E. Progress in medicinal chemistry. (1996) [Pubmed]
  26. Gene structural analysis and expression of human renal dipeptidase. Satoh, S., Ohtsuka, K., Keida, Y., Kusunoki, C., Konta, Y., Niwa, M., Kohsaka, M. Biotechnol. Prog. (1994) [Pubmed]
  27. Validation of ultrafiltration as a method of measuring free 99mTc-MDP. Moore, A.E., Hain, S.F., Blake, G.M., Fogelman, I. J. Nucl. Med. (2003) [Pubmed]
WikiGenes - Universities