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Gene Review

ObPVgp1  -  180K protein

Obuda pepper virus

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High impact information on ObPVgp1

  • Three (two frame-shift and one non-sense) mutants with an intact 130K but a defective 180K protein gene were not infectious, while two mutants with a one-amino-acid insertion in the 180K protein gene were infectious [1].
  • Complete nucleotide sequencing of the TMV-R genomic RNA revealed amino acid changes in the 130K/ 180K replicase proteins, the 30K protein, and the coat protein and nucleotide changes in the 5' and 3' noncoding regions compared to TMV-U1 [2].
  • Examination of the infection phenotypes of the 14 constructed chimeric viruses in BY showed that determinants defining the differential infection phenotype in BY reside in the 130K/180K replicase proteins and the 3' noncoding region [2].

Biological context of ObPVgp1

  • The 130K (1,115 amino acids), 180K (1,615 amino acids), 30K (263 amino acids) and coat protein (158 amino acids) cistrons are located at residues 72-3442, 72-4922, 4906-5700, and 5703-6182 on the genome, respectively [3].
  • Only three, which were in the common reading frame for both the 130K and 180K proteins, resulted in amino acid changes [4].
  • The amino acid sequence homologies of the four encoded proteins (180K, 130K, 30K, coat protein) are from 95.9% to 98.0% compared with TMV-U1 [5].

Other interactions of ObPVgp1

  • Remarkable differences between them were found in a part of the N-terminal portion of the 130K/180K protein and the C-terminal portion of the 30K protein [3].


  1. In vitro mutagenesis of the putative replicase genes of tobacco mosaic virus. Ishikawa, M., Meshi, T., Motoyoshi, F., Takamatsu, N., Okada, Y. Nucleic Acids Res. (1986) [Pubmed]
  2. Mapping of host range restriction of the rakkyo strain of tobacco mosaic virus in Nicotiana tabacum cv. bright yellow. Chen, J., Watanabe, Y., Sako, N., Ohshima, K., Okada, Y. Virology (1996) [Pubmed]
  3. Nucleotide sequence of the tobacco mosaic virus (tomato strain) genome and comparison with the common strain genome. Ohno, T., Aoyagi, M., Yamanashi, Y., Saito, H., Ikawa, S., Meshi, T., Okada, Y. J. Biochem. (1984) [Pubmed]
  4. Molecular basis of plant viral virulence; the complete nucleotide sequence of an attenuated strain of tobacco mosaic virus. Nishiguchi, M., Kikuchi, S., Kiho, Y., Ohno, T., Meshi, T., Okada, Y. Nucleic Acids Res. (1985) [Pubmed]
  5. Complete nucleotide sequence and synthesis of infectious in vitro transcripts from a full-length cDNA clone of a rakkyo strain of tobacco mosaic virus. Chen, J., Watanabe, Y., Sako, N., Ohshima, K., Okada, Y. Arch. Virol. (1996) [Pubmed]
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