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Gene Review

ObPVgp2  -  130K protein

Obuda pepper virus

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Disease relevance of ObPVgp2


High impact information on ObPVgp2

  • Three (two frame-shift and one non-sense) mutants with an intact 130K but a defective 180K protein gene were not infectious, while two mutants with a one-amino-acid insertion in the 180K protein gene were infectious [2].
  • Taken together, these results indicate that it is likely that the ToMV-encoded suppressor, the 130K replication protein, blocks the utilization of silencing-associated small RNAs, so that a homology-dependent RNA degradation machinery is not newly formed [3].
  • The four genes (130K, 180K, 30K and coat protein) could then be mapped at precise locations in the TMV genome [4].

Biological context of ObPVgp2

  • Only three, which were in the common reading frame for both the 130K and 180K proteins, resulted in amino acid changes [5].
  • Examination of the infection phenotypes of the 14 constructed chimeric viruses in BY showed that determinants defining the differential infection phenotype in BY reside in the 130K/180K replicase proteins and the 3' noncoding region [6].

Other interactions of ObPVgp2

  • Remarkable differences between them were found in a part of the N-terminal portion of the 130K/180K protein and the C-terminal portion of the 30K protein [7].


  1. Nucleotide sequence of tobamovirus Ob which can spread systemically in N gene tobacco. Ikeda, R., Watanabe, E., Watanabe, Y., Okada, Y. J. Gen. Virol. (1993) [Pubmed]
  2. In vitro mutagenesis of the putative replicase genes of tobacco mosaic virus. Ishikawa, M., Meshi, T., Motoyoshi, F., Takamatsu, N., Okada, Y. Nucleic Acids Res. (1986) [Pubmed]
  3. Tomato mosaic virus replication protein suppresses virus-targeted posttranscriptional gene silencing. Kubota, K., Tsuda, S., Tamai, A., Meshi, T. J. Virol. (2003) [Pubmed]
  4. Historical overview of research on the tobacco mosaic virus genome: genome organization, infectivity and gene manipulation. Okada, Y. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1999) [Pubmed]
  5. Molecular basis of plant viral virulence; the complete nucleotide sequence of an attenuated strain of tobacco mosaic virus. Nishiguchi, M., Kikuchi, S., Kiho, Y., Ohno, T., Meshi, T., Okada, Y. Nucleic Acids Res. (1985) [Pubmed]
  6. Mapping of host range restriction of the rakkyo strain of tobacco mosaic virus in Nicotiana tabacum cv. bright yellow. Chen, J., Watanabe, Y., Sako, N., Ohshima, K., Okada, Y. Virology (1996) [Pubmed]
  7. Nucleotide sequence of the tobacco mosaic virus (tomato strain) genome and comparison with the common strain genome. Ohno, T., Aoyagi, M., Yamanashi, Y., Saito, H., Ikawa, S., Meshi, T., Okada, Y. J. Biochem. (1984) [Pubmed]
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