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Gene Review

betT  -  choline transporter of high affinity

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0312, JW0306
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Disease relevance of betT


High impact information on betT

  • In an accompanying paper we report that the betT and betI promoters are divergently organized and partially overlapping and that both are negatively regulated by BetI in response to choline [2].
  • Choline further induced expression of lac fusions at the betA, betB, and betT loci when the cells were grown under conditions of osmotic stress [3].
  • Tolerance appears to involve increased metabolism of glycine (higher expression of gcv genes) and increased production of betaine (higher expression of betIBA and betT encoding betaine synthesis from choline and choline uptake, respectively) [4].
  • The betB and the betT genes were named in this paper, and the clockwise gene order was shown to be betA,B,T [5].


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