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Gene Review:

betT - choline transporter of high affinity

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0312, JW0306

Gonzalez, R. et al., Rkenes, T.P. et al., Fan, X. et al., Eshoo, M.W., Andresen, P.A. et al.

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Disease relevance of betT

The betT gene in H. influenzae is similar to betT in Escherichia coli, which functions in choline transport for the generation of betaine in osmoprotection [1].

High impact information on betT

In an accompanying paper we report that the betT and betI promoters are divergently organized and partially overlapping and that both are negatively regulated by BetI in response to choline [2].
Choline further induced expression of lac fusions at the betA, betB, and betT loci when the cells were grown under conditions of osmotic stress [3].
Tolerance appears to involve increased metabolism of glycine (higher expression of gcv genes) and increased production of betaine (higher expression of betIBA and betT encoding betaine synthesis from choline and choline uptake, respectively) [4].
The betB and the betT genes were named in this paper, and the clockwise gene order was shown to be betA,B,T [5].

References

Multiple mechanisms for choline transport and utilization in Haemophilus influenzae. Fan, X., Pericone, C.D., Lysenko, E., Goldfine, H., Weiser, J.N. Mol. Microbiol. (2003) [Pubmed]
DNA-binding properties of the BetI repressor protein of Escherichia coli: the inducer choline stimulates BetI-DNA complex formation. Rkenes, T.P., Lamark, T., Strøm, A.R. J. Bacteriol. (1996) [Pubmed]
lac fusion analysis of the bet genes of Escherichia coli: regulation by osmolarity, temperature, oxygen, choline, and glycine betaine. Eshoo, M.W. J. Bacteriol. (1988) [Pubmed]
Gene array-based identification of changes that contribute to ethanol tolerance in ethanologenic Escherichia coli: comparison of KO11 (parent) to LY01 (resistant mutant). Gonzalez, R., Tao, H., Purvis, J.E., York, S.W., Shanmugam, K.T., Ingram, L.O. Biotechnol. Prog. (2003) [Pubmed]
Molecular cloning, physical mapping and expression of the bet genes governing the osmoregulatory choline-glycine betaine pathway of Escherichia coli. Andresen, P.A., Kaasen, I., Styrvold, O.B., Boulnois, G., Strøm, A.R. J. Gen. Microbiol. (1988) [Pubmed]

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