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Gene Review

tig  -  peptidyl-prolyl cis/trans isomerase...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0430, JW0426
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Disease relevance of tig


High impact information on tig


Anatomical context of tig

  • While signal recognition particle and Trigger factor might remain bound to the same ribosome, both ligands are clearly able to displace each other from a nascent chain [6].

Analytical, diagnostic and therapeutic context of tig


  1. Sequence and transcriptional analysis of clpX, a class-III heat-shock gene of Bacillus subtilis. Gerth, U., Wipat, A., Harwood, C.R., Carter, N., Emmerson, P.T., Hecker, M. Gene (1996) [Pubmed]
  2. Trigger factor depletion or overproduction causes defective cell division but does not block protein export. Guthrie, B., Wickner, W. J. Bacteriol. (1990) [Pubmed]
  3. Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed. Agashe, V.R., Guha, S., Chang, H.C., Genevaux, P., Hayer-Hartl, M., Stemp, M., Georgopoulos, C., Hartl, F.U., Barral, J.M. Cell (2004) [Pubmed]
  4. The "trigger factor cycle" includes ribosomes, presecretory proteins, and the plasma membrane. Lill, R., Crooke, E., Guthrie, B., Wickner, W. Cell (1988) [Pubmed]
  5. The Oenococcus oeni clpX homologue is a heat shock gene preferentially expressed in exponential growth phase. Jobin, M.P., Garmyn, D., Diviès, C., Guzzo, J. J. Bacteriol. (1999) [Pubmed]
  6. Alternate recruitment of signal recognition particle and trigger factor to the signal sequence of a growing nascent polypeptide. Eisner, G., Moser, M., Schäfer, U., Beck, K., Müller, M. J. Biol. Chem. (2006) [Pubmed]
  7. ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle. Crooke, E., Guthrie, B., Lecker, S., Lill, R., Wickner, W. Cell (1988) [Pubmed]
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