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Gene Review

ubiF  -  2-octaprenyl-3-methyl-6-methoxy-1,4...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0654, JW0659, yleB
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Disease relevance of ubiF

  • We obtained mutants with Tn5 inserted in asnB. asnB was mapped by conjugation and by three-factor P1 transductions at 15 min on the E coli K-12 linkage map, between ubiF and nagB [1].

High impact information on ubiF

  • Here we show that the plasmid encoding C. elegans CLK-1 supported aerobic respiration on a non-fermentable carbon source of E. coli ubiF mutant strain and rescued the ability to synthesize ubiquinone, suggesting that the eukaryotic CLK-1/Coq7p family could function as bacterial UbiF [2].
  • Some of these characteristics, together with mapping data, suggested that the phleomycin resistance and Suc- determinant probably lies within the ubiF gene coding for an enzyme effecting a step in the biosynthesis of ubiquinone [3].
  • Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene [4].
  • The ubiF encoded oxygenase introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1, 4-benzoquinol [4].
  • The ubiF mutants, when complemented with this plasmid, regained the ability to grow on succinate and synthesize Q [4].


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