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Gene Review:

HOMER3 - homer homolog 3 (Drosophila)

Homo sapiens

Synonyms: HOMER-3, Homer protein homolog 3, Homer-3, VESL3

Ishiguro, K. et al., Zuliani, L. et al.

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Disease relevance of HOMER3

Homer 3 autoimmunity in subacute idiopathic cerebellar ataxia [1].

High impact information on HOMER3

Homer-3 regulates activation of serum response element in T cells via its EVH1 domain [2].
Overexpression of Homer-3 reduced transcriptional activation via the serum response element (SRE) in response to anti-CD3 antibody, phorbol ester, or dominant active Ha-Ras [2].
Homer-3 coprecipitated with CCAAT/enhancer binding protein beta (C/EBP beta), one of the transcription factors that binds to the SRE and has a consensus motif binding to EVH1 domain [2].
Homer-3, a member of the EVH1 family, is expressed in the thymus, suggesting a role for this protein in T-cell signal transduction [2].

References

Homer 3 autoimmunity in subacute idiopathic cerebellar ataxia. Zuliani, L., Sabater, L., Saiz, A., Baiges, J.J., Giometto, B., Graus, F. Neurology (2007) [Pubmed]
Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. Ishiguro, K., Xavier, R. Blood (2004) [Pubmed]

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HOMER3	Bos taurus
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homer3	Danio rerio
HOMER3	Gallus gallus
HOMER3	Macaca mulatta
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Homer3	Rattus norvegicus
homer3	Xenopus (Silurana) tropicalis

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