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Gene Review:

sdhA - succinate dehydrogenase, flavoprotein subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0712, JW0713

Magnusson, K. et al., Heinzen, R.A. et al., Aliabadi, Z. et al., Hasnain, S. et al.

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Disease relevance of sdhA

In addition, analysis of the nt sequence immediately upstream from R. prowazekii sdhA revealed that the rickettsial sdh gene organization differs from that of E. coli and B. subtilis [1].
Cloning and deletion analysis of a genomic segment of Bacillus subtilis coding for the sdhA, B, C (succinate dehydrogenase) and gerE (spore germination) loci [2].

High impact information on sdhA

The plasmid clone pLPM60, which carries the C. burnetii sdhCDAB coding and upstream regulatory regions, rescued an E. coli sdhA mutant (MOB252), indicating functional expression of the rickettsial locus [3].
About 30 bases downstream of the sdhA stop codon, a new open reading frame starts [4].
Seven bases upstream of the sdhA initiation codon ATG there is a typical B. subtilis ribosome binding site (free energy of interaction, -63 kJ), and further upstream, tentative sigma 55 and sigma 32 promoter sequences were found [4].

References

Isolation and characterization of the Rickettsia prowazekii gene encoding the flavoprotein subunit of succinate dehydrogenase. Aliabadi, Z., Winkler, H.H., Wood, D.O. Gene (1993) [Pubmed]
Cloning and deletion analysis of a genomic segment of Bacillus subtilis coding for the sdhA, B, C (succinate dehydrogenase) and gerE (spore germination) loci. Hasnain, S., Sammons, R., Roberts, I., Thomas, C.M. J. Gen. Microbiol. (1985) [Pubmed]
Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii. Heinzen, R.A., Mo, Y.Y., Robertson, S.J., Mallavia, L.P. Gene (1995) [Pubmed]
Nucleotide sequence of the gene for cytochrome b558 of the Bacillus subtilis succinate dehydrogenase complex. Magnusson, K., Philips, M.K., Guest, J.R., Rutberg, L. J. Bacteriol. (1986) [Pubmed]

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