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Gene Review

sdhA  -  succinate dehydrogenase, flavoprotein subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0712, JW0713
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Disease relevance of sdhA

  • In addition, analysis of the nt sequence immediately upstream from R. prowazekii sdhA revealed that the rickettsial sdh gene organization differs from that of E. coli and B. subtilis [1].
  • Cloning and deletion analysis of a genomic segment of Bacillus subtilis coding for the sdhA, B, C (succinate dehydrogenase) and gerE (spore germination) loci [2].

High impact information on sdhA

  • The plasmid clone pLPM60, which carries the C. burnetii sdhCDAB coding and upstream regulatory regions, rescued an E. coli sdhA mutant (MOB252), indicating functional expression of the rickettsial locus [3].
  • About 30 bases downstream of the sdhA stop codon, a new open reading frame starts [4].
  • Seven bases upstream of the sdhA initiation codon ATG there is a typical B. subtilis ribosome binding site (free energy of interaction, -63 kJ), and further upstream, tentative sigma 55 and sigma 32 promoter sequences were found [4].


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