Gene Review:
lpxK - lipid A 4'kinase
Escherichia coli str. K-12 substr. MG1655
Synonyms:
ECK0906, JW0898, ycaH
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Disease relevance of lpxK
- The lpxK gene has been proposed to encode the lipid A 4'-kinase in Escherichia coli (Garrett, T. A., Kadrmas, J. L., and Raetz, C. R. H. (1997) J. Biol. Chem. 272, 21855-21864) [1].
- Homologs of lpxK are present in the genomes of other Gram-negative bacteria [1].
High impact information on lpxK
- When this strain (designated TG1/pTAG1) is grown at 44 degreesC, the plasmid bearing the lpxK+ is lost, and the phenotype of an lpxK knock-out mutation is unmasked [1].
- This mutation is complemented at 30 degreesC by a hybrid plasmid with a temperature-sensitive origin of replication carrying lpxK+ [1].
- The growth of TG1/pTAG1 was inhibited after several hours at 44 degreesC, consistent with lpxK being an essential gene [1].
- We have now constructed a strain in which only the lpxK gene is inactivated by inserting a kanamycin cassette into the chromosomal copy of lpxK [1].
References
- Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. Garrett, T.A., Que, N.L., Raetz, C.R. J. Biol. Chem. (1998) [Pubmed]
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