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Gene Review

lpxK  -  lipid A 4'kinase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0906, JW0898, ycaH
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Disease relevance of lpxK


High impact information on lpxK

  • When this strain (designated TG1/pTAG1) is grown at 44 degreesC, the plasmid bearing the lpxK+ is lost, and the phenotype of an lpxK knock-out mutation is unmasked [1].
  • This mutation is complemented at 30 degreesC by a hybrid plasmid with a temperature-sensitive origin of replication carrying lpxK+ [1].
  • The growth of TG1/pTAG1 was inhibited after several hours at 44 degreesC, consistent with lpxK being an essential gene [1].
  • We have now constructed a strain in which only the lpxK gene is inactivated by inserting a kanamycin cassette into the chromosomal copy of lpxK [1].


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