Disease relevance of rmf

• Regulation of the Escherichia coli rmf gene encoding the ribosome modulation factor: growth phase- and growth rate-dependent control [1].

High impact information on rmf

• The katF gene product, a stationary phase-specific sigma factor, was not required for the expression of rmf [1].
• Disruption of rmf resulted in loss of ribosome dimers and reduction of cell viability during stationary phase [1].
• Under slow growth conditions, rmf was expressed even in exponential phase and there was an inverse relationship between the expression of rmf and the cell growth rate [1].
• The structural gene, rmf, encoding the 55 amino acid residues RMF protein has been cloned from the 21.8 min region of the E. coli genome and sequenced [1].
• Nor did it appear to have a significant effect on cell survival under acid stress since the vulnerability of an RMF-deficient mutant strain was similar to that of the parent strain [2].

Biological context of rmf

• Enhancement of cell death due to decrease in Mg2+ uptake by OmpC (cation-selective porin) deficiency in ribosome modulation factor-deficient mutant [3].

Associations of rmf with chemical compounds

• Thus, a decrease in RMF levels may be involved in the decreased cell viability caused by excess spermidine [3].

Other interactions of rmf

• To clarify that these three proteins are strongly involved in cell viability, the rmf, rpoS (encoding sigma(38)), and ompC genes were disrupted [4].

References