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Gene Review

rmf  -  ribosome modulation factor

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0944, JW0936
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Disease relevance of rmf


High impact information on rmf

  • The katF gene product, a stationary phase-specific sigma factor, was not required for the expression of rmf [1].
  • Disruption of rmf resulted in loss of ribosome dimers and reduction of cell viability during stationary phase [1].
  • Under slow growth conditions, rmf was expressed even in exponential phase and there was an inverse relationship between the expression of rmf and the cell growth rate [1].
  • The structural gene, rmf, encoding the 55 amino acid residues RMF protein has been cloned from the 21.8 min region of the E. coli genome and sequenced [1].
  • Nor did it appear to have a significant effect on cell survival under acid stress since the vulnerability of an RMF-deficient mutant strain was similar to that of the parent strain [2].

Biological context of rmf


Associations of rmf with chemical compounds


Other interactions of rmf

  • To clarify that these three proteins are strongly involved in cell viability, the rmf, rpoS (encoding sigma(38)), and ompC genes were disrupted [4].


  1. Regulation of the Escherichia coli rmf gene encoding the ribosome modulation factor: growth phase- and growth rate-dependent control. Yamagishi, M., Matsushima, H., Wada, A., Sakagami, M., Fujita, N., Ishihama, A. EMBO J. (1993) [Pubmed]
  2. The activity of ribosome modulation factor during growth of Escherichia coli under acidic conditions. el-Sharoud, W.M., Niven, G.W. Arch. Microbiol. (2005) [Pubmed]
  3. Enhancement of cell death due to decrease in Mg2+ uptake by OmpC (cation-selective porin) deficiency in ribosome modulation factor-deficient mutant. Apirakaramwong, A., Fukuchi, J., Kashiwagi, K., Kakinuma, Y., Ito, E., Ishihama, A., Igarashi, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  4. Decrease in cell viability in an RMF, sigma(38), and OmpC triple mutant of Escherichia coli. Samuel Raj, V., Füll, C., Yoshida, M., Sakata, K., Kashiwagi, K., Ishihama, A., Igarashi, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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